中国实用妇科与产科杂志2017，Vol.33Issue(6)：655-658,4.DOI:10.19538/j.fk2017060125
miR-23及孕激素受体蛋白在子宫肌瘤组织中表达及临床意义研究
The study on the expression of miR-23、 pr receptor protein in uterus leiomyoma and its clinical significance
史凡黎 1宋燕 1王敏 2刘易斯 1史聪1
作者信息
- 1. 中国医科大学附属盛京医院妇产科,辽宁沈阳110004
- 2. 济南市妇幼保健院,山东济南250001
- 折叠
摘要
Abstract
Objective To analyze the expressions of miR-23 and PR protein in uterine leiomyoma in order to find their clinical significance.Methods The realtime-PCR and Western blot methods were used to detect the expressions of miR-23 and PR protein.Results The expression of miR-23 in extracapsular myometrium and normal myometrium is higher than which in uterine leiomyoma tissue,and the differences both have significance (P＜0.001).PRA and PRB protein are highly expressed in uterine leiomyoma,the low expression in the groups of normal myometrium and corresponding extracapsular myometrium,the differences both have significance (P＜0.001).In corresponding extracapsular myometrium and normal myometrium,the difference of PRA protein content has no significance (P=0.198),the difference of PRB protein content has significance (P=0.035).In uterine leiomyoma,the difference of the relative content of PRA and PRB protein has no significance (P=0.389).miR-23 and PRA protein are negative correlated in uterine leiomyoma tissue (r=-0.754),miR-23 and PRB protein have no correlation(r=-0.394).Conclusion miR-23 and PR have relationship with the development of uterine leiomyoma.PR is one of the target genes of miR-23,which can lead to an increase of PRA protein in the level of transcription.关键词
子宫肌瘤/miR-23/孕激素受体A/孕激素受体BKey words
uterine leiomyoma/miR-23/PRA/PRB分类
医药卫生引用本文复制引用
史凡黎,宋燕,王敏,刘易斯,史聪..miR-23及孕激素受体蛋白在子宫肌瘤组织中表达及临床意义研究[J].中国实用妇科与产科杂志,2017,33(6):655-658,4.
