中国实用口腔科杂志2017，Vol.10Issue(5)：270-273,4.DOI:10.19538/j.kq.2017.05.004
直接激光打印种植体对糖尿病小型猪早期骨结合影响研究
Influence of direct laser metal sintering implants on the early stages of osseointegration in diabetic mini-pigs.
摘要
Abstract
Objective The diabetic pig model was established by intravenous injection of streptozocin in order to investigate whether direct laser metal sintering (DLMS)could improve osseointegration in diabetic animal models.Methods A diabetes model in mini-pigs was established by intravenous injection of streptozotocin (STZ)(150 mg/kg),and a total of 36 implants were inserted into the nandibular region.Micro-computed tomography (micro-CT)and histologic evaluations were performed three and six months after implantation.Results The blood glucose level remained at high level (≥ 10 mmol/L) after the induction of diabetes,reaching the diabetic level (≥ 7 mmol/L).Obvious improvement in osseointegration was observed in the micro-CT and Van Gieson (VG)staining analyses of DLMS implants compared with MAO at three months (P ＜ 0.05),although this difference disappeared by six months (P ＞ 0.05).Conclusion The rough surface of DLMS implants can accelerate the progress of osseointegration.关键词
激光制造/牙种植体/糖尿病/骨结合Key words
laser manufacturing/dental implants/diabetes mellitus/osseointegration分类
医药卫生引用本文复制引用
谭乃文,张思佳,魏洪波,许晓茹,刘向伟,任帅,周宇超,宋应亮..直接激光打印种植体对糖尿病小型猪早期骨结合影响研究[J].中国实用口腔科杂志,2017,10(5):270-273,4.基金项目
国家自然科学基金(81170984 （）
81470775) （）
