中国实用口腔科杂志2017，Vol.10Issue(5)：283-286,4.DOI:10.19538/j.kq.2017.05.007
生物活性透明质酸联合盐酸米诺环素对牙龈卟啉单胞菌抑菌作用研究
Effect of bioactive hyaluronic acid combined with minocycline hydrochloride on the antibacterial function of Porphyromonas gingivalis
陈菲 1庄德舒 1张洪波 1栾晓敏 1毕良佳1
作者信息
- 1. 哈尔滨医科大学附属第四医院口腔科,黑龙江 哈尔滨 150001
- 折叠
摘要
Abstract
Objective To invesigate the combined effect of bioactive hyaluronic acid (B-HA) with minocycline hydrochloride on the antibacterial function of Porphyromonas gingivalis (P.gingivalis),to provide a therory to the clinical of periodontal medicine.Methods Agar dilution method with medicine to measure the survive rate of P.gingivalis,divided into four groups,B-HA separately,minocycline hydrochloride separately,B-HA combined minocycline hydrochloride,control group accordingly.Quantitated the ability of P.gingivalis is growth by counting the number of the visible bacterial colony,and computed the survival rate of P.gingivalis.Results Five different density of B-HA combined the minocycline hydrochloride in a density of 0.05 μg/L,the result showed as the increase of B-HA,the survival rate is decrease gradually (P ＜ 0.05),the survival rate is 82.57％,71.56％ seperately when the density is 35 mg/L and 45 mg/L respectively.The survival rate is 50.46％ when the density is 55 mg/L.Compared to the B-HA alone,it has improved at 22.93％ (P ＜ 0.05).Conclusion Our research show that the combination between B-HA and minocycliue hydrochloride has signifiant effect on the anti-bacterial of P.gingivalis.关键词
透明质酸/牙龈卟啉单胞菌/米诺环素/联合抑菌/琼脂平板稀释法Key words
hyaluronic acid, HA/Porphyromonas gingivalis/minocycline hydrochloride/combined antibacterial effect/agar dilution method分类
医药卫生引用本文复制引用
陈菲,庄德舒,张洪波,栾晓敏,毕良佳..生物活性透明质酸联合盐酸米诺环素对牙龈卟啉单胞菌抑菌作用研究[J].中国实用口腔科杂志,2017,10(5):283-286,4.
