中国体外循环杂志2017，Vol.15Issue(2)：109-112,108,5.DOI:10.13498/j.cnki.chin.j.ecc.2017.02.11
褪黑素通过减轻内质网应激抵抗多柔比星心脏毒性
Melatonin protects heart against Doxorubicin-induced cardiotoxicity partly through inhibiting cardiac endoplasmic reticulum stress
摘要
Abstract
Objective To study the effect of melatonin ( Mel) on doxorubicin ( DOX)-induced cardiotoxicity and endo-plasmic reticulum ( ER) stress. Methods Male C57BL/6 mice ( 20-25g) were subject to a single intraperitoneal injection of doxorubicin (DOX, 15 mg/kg). Animals were randomly divided into three groups: Control group (n=20), DOX group (n=20) and DOX+Mel group ( n=20) . Five days after DOX injection, cardiac function, heart rate, myocardial apoptotic ratio, and the expression of p-PERK, PERK, p-eIF2α,eIF2αand CHOP were measured. Results Mel treatment significantly improved the car-diac functional recovery, increased heart rate and reduced myocardial injury and apoptosis. Additionally, Mel treatment significantly decreased the p-PERK/PERK ratio, p-eIF2α/eIF2αratio and CHOP expression following DOX treatment ( all P<0.05) . Conclusion Our results show that melatonin protects the heart against DOX-induced cardiotoxicity by reducing ER stress.关键词
褪黑素/多柔比星/心脏毒性/内质网应激Key words
Melatonin/Doxorubicin/Cardiotoxicity/ER stress引用本文复制引用
李步潆,翟蒙恩,张彬,刘振华,于立明,王晓武,金振晓,段维勋,俞世强..褪黑素通过减轻内质网应激抵抗多柔比星心脏毒性[J].中国体外循环杂志,2017,15(2):109-112,108,5.基金项目
国家自然科学基金项目资助( 81570231, 81570230,81470415) （ 81570231, 81570230,81470415）
