中国现代医学杂志2017，Vol.27Issue(11)：41-44,4.DOI:10.3969/j.issn.1005-8982.2017.11.008
C-myc基因表达及细胞凋亡在脂溢性角化病皮损中的意义
Significance of C-myc expression and cell apoptosis in seborrheic keratosis
杜镇 1海艺贝 2冯世军 3王艳心 1王成 1李保强1
作者信息
- 1. 承德医学院附属医院,河北 承德 067000
- 2. 广州中医药大学,广东 广州 510000
- 3. 河北省沧州市中心医院,河北 沧州 061000
- 折叠
摘要
Abstract
Objective To observe the expression of C-myc and apoptosis in seborrheic keratosis (SK) and investigate the pathogenesis of SK. Methods Imunohistochemistry was used to detect the expression of C-myc, and the apoptosis of cell were detected by TUNEL in 66 SK lesions and 10 normal controls. Results There was no significant difference in gender and age between the two groups (P>0.05). The percentage of C-myc positive cells (21.94 ± 19.45) % in SK lesions were significantly higher than that in the control groups (0) (P <0.05). The protein of C-myc was positively expressed in 52 cases of the 66 SK lesions while none was expressed in the control groups (P<0.05). There was no significant difference in apoptotic index between SK lesions (53.01 ± 31.97) and the control groups (33.50 ± 23.86) by TUNEL (P>0.05). There were no significant correlation between the percentage of C-myc protein positive cells and the apoptosis index in SK lesions by spearman analysis (P>0.05). Conclusions C-myc protein is involved in the occurrence and development of SK, and the apoptosis of SK is increased.关键词
脂溢性角化病/免疫组织化学/C-myc基因/脱氧核糖核苷酸末端转移酶介导的缺口末端标记Key words
seborrheic keratosis/immunohistochemistry/C-myc/TUNEL分类
医药卫生引用本文复制引用
杜镇,海艺贝,冯世军,王艳心,王成,李保强..C-myc基因表达及细胞凋亡在脂溢性角化病皮损中的意义[J].中国现代医学杂志,2017,27(11):41-44,4.
