摘要
Abstract
Objective To systematically review the curative effect of compound salvia injection in treatment of acute exacerbation with chronic pulmonary heart disease. Methods Data in Cochrane Library, PubMed, EMbase, CNKI, CBMdisc, VIP and Wan Fang were searched to collect randomized controlled trials (RCTs) of compound salvia injection in treatment of acute exacerbation of chronic pulmonary heart disease from January 1997 to December 2015. Literature and data were screened and extracted by two reviewers independently, and the quality of the inclusion researches had estimated by Jadad scale. Meta-analysis was performed by RevMan 5.3 software. Results A total of 17 studies were included. The results of meta-analysis showed: the compound salvia injection group was superior to control group in enhance total effective rate [Z =7.49, P=0.00, O^R=2.39, 95%CI (1.91, 3.01)] and partial pressure of oxygen [MD=1.96, 95%CI (0.91, 3.02), P= 0.00]. The compound salvia injection group was superior to the control group in reducing plasma viscosity [MD=-0.10, 95%CI (-0.18, -0.02), P=0.01] and partial pressure of carbon dioxide [MD=-0.97, 95%CI (-1.27, -0.67), P=0.00]. There were no statistical differences in packed cell volum and erythrocyte sedimentation rate between compound salvia injection and control groups (P> 0.05). Conclusions Compound salvia injection has better therapeutic effect on acute exacerbation of chronic pulmonary heart disease. The results should be verified by more high quality and large-scale sample randomized control trials because the limited quantity and quality of present research.关键词
复方丹参注射液/慢性肺心病/急性加重期/Meta分析Key words
compound salvia injection/chronic pulmonary heart disease/acute exacerbation/Meta-analysis分类
医药卫生
