中国现代医学杂志2017，Vol.27Issue(11)：112-116,5.DOI:10.3969/j.issn.1005-8982.2017.11.024
无锡地区孕早期产前筛查指标中位数的建立及临床意义
Establishment of median value for screening serum-markers in first-trimester prenatal screening and investigation of its clinical significance in Wuxi
摘要
Abstract
Objective To establish the median equation of serum free β-human chorionic gonadotropin (free β-HCG), pregnancy-associated plasma protein A (PAPP-A) in the first trimester in Wuxi, and to evaluate the influence of the local adjustment of the median equation on the screening efficiency. Methods A total of 5,294 gravidas [9 to 13 (+6) gestational weeks] underwent a screening test of double serum markers including free β-HCG, PAPP-A by automatic time-resolved fluorescence immunoassay analyzer (TRFIA). The risks of Downs syndrome, Edward syndrome were evaluated by Life Cycle 4.0 software. The median values of free β-hCG, PAPP-A were analyzed with statistical software, and the median regression equation of free β-hCG and PAPP-A in suited local pregnant women with different gestational weeks was established. Then the risks of the screening data were re-evaluated. Combined with prenatal diagnosis of chromosomal karyotype results and pregnancy outcomes and pregnant women followed up, the screening efficiency between the two median equa-tions was compared. Results Compared with gaucasian markers of built-in software, the median level for serum β-HCG and PAPP-A were higher on average respectively after revised gestational age and weight (freeβ-HCG: P>0.05, PPAPP-A: P<0.05). The detection rates for trisomy 21 were 85.4% in local median equation and 71.4% in the software built-in one. The faulse positive rates for trisomy 21 were 4.59% in local median equation and 4.74%% in the software built-in one. Conclusions There are significant differences on the race and region when using the LifeCycle 4.0 median equations. It is very important to establish the local median equation based on revised gestation age and weight in the first trimester for prenatal serum screening test. Adjusted local median can help to improve the screening efficiency of prenatal screening.关键词
产前筛查/孕早期/中位数/游离β-人绒毛膜促性腺激素/妊娠相关蛋白A/体重Key words
prenatal screening/first trimester/median/free β-HCG/PAPP-A/weight分类
医药卫生引用本文复制引用
石皓,吴晓,王峻峰,肖建平,杨灿峰,赵丽,杨岚..无锡地区孕早期产前筛查指标中位数的建立及临床意义[J].中国现代医学杂志,2017,27(11):112-116,5.基金项目
无锡市医管中心面上项目(No:YGZXM1510) （No:YGZXM1510）
无锡市科技发展基金项目(No:CSE31N1511) （No:CSE31N1511）
江苏省妇幼保健重点资助项目(No:F201315) （No:F201315）
