中国现代医学杂志2017，Vol.27Issue(12)：21-24,4.DOI:10.3969/j.issn.1005-8982.2017.12.004
血必净治疗腹腔感染的实验研究
Therapeutic effect and mechanism of Xuebijing on intra-abdominal infection of rats*
摘要
Abstract
Objective To investigate the protective effect of Xuebijing (XBJ) on the acute pancreatitis in rats and its possible mechanism. Methods Thirty SD rats were randomized into sham group, pancreatitis group and XBJ group. The rats in the sham group only underwent opening and closure of the abdomen; the rats in the pancreatitis group received Taurocholate sodium administration to establish animal model and the treatment group was intervened by XBJ. The pathological changes of pancreatic tissues were observed under optic micro-scope. Plasma concentrations of amylase and the expressions of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in pancreatic tissues were determined by ELISA. Apoptosis of isolated neutrophiles was detected. Results The pathological changes of the pancreatic tissues in the XBJ group were much more relieved compared to those in the pancreatitis group; the level of blood amylase was significantly lower in the XBJ group (P<0.05). The expressions of TNF-α and IL-6 in the XBJ group were significantly lower than those in the pancreatitis group (P<0.05). The PMN apoptotic rate in the XBJ group was not significantly different from that in the pancreatitis group (P> 0.05). Conclusions XBJ could relieve acute pancreatitis in rats by inhibiting the production of TNF-α and IL-6. Whether it could promote apoptosis of PMN needs further research.关键词
血必净/急性胰腺炎/肿瘤坏死因子/中性粒细胞/凋亡Key words
Xuebijing/acute pancreatitis/tumor necrosis factor-α/neutrophile/apoptosis分类
医药卫生引用本文复制引用
张玮,朱艳娜,刘守信..血必净治疗腹腔感染的实验研究[J].中国现代医学杂志,2017,27(12):21-24,4.基金项目
2013年辽宁省教育厅科学研究一般项目(No:L2013355) （No:L2013355）
