中国现代医学杂志2017，Vol.27Issue(12)：55-59,5.DOI:10.3969/j.issn.1005-8982.2017.12.011
SH2B1基因多态性与妊娠糖尿病的相关性研究
Association of SH2B1 gene polymorphism with gestational diabetes mellitus
孙桂霞 1王宁 1张红霞 1杨少琴1
作者信息
- 1. 河南大学淮河医院 妇产科,河南 开封 475000
- 折叠
摘要
Abstract
Objective To investigate the relationship between SH2B1 gene polymorphism and insulin resis-tance in patients with gestational diabetes mellitus (GDM). Methods Totally 164 GDM patients and 130 normal pregnant women with impaired glucose tolerance were selected. The SH2B1 genotype was detected by poly-merase chain reaction-restriction fragment length polymorphism and then the clinical data were analyzed. Results There was significant difference between the GA and GG genotypes of SH2B1 (rs4788102) in the GDM group [ O^R=1.531, (95%CI: 1.093, 2.374), P=0.04]. There was significant difference in the A allele frequency and the G allele frequency in the GDM group [ O^R=1.436, (95%CI: 1.091, 1.972), P=0.01]. In the GDM group, the GA and AA genotypes were significantly different from the GG genotype [ O^R=1.699, (95%CI: 1.185, 2.479), P= 0.02]. BMI, TG, leptin, and HOMA-IR were significantly different between the GDM patients with AA or GA genotype and those with GG genotype (P<0.05). Logistic regression analysis showed that GA and AA genotypes were the risk factors for HOMA-IR elevation. Conclusions SH2B1 (rs4788102) gene polymorphism may be a susceptible locus of GDM, which could be used to predict the risk of GDM in pregnant women.关键词
妊娠糖尿病/SH2B1基因多态性/胰岛素抵抗Key words
gestational diabetes mellitus/SH2B1 gene polymorphism/insulin resistance分类
医药卫生引用本文复制引用
孙桂霞,王宁,张红霞,杨少琴..SH2B1基因多态性与妊娠糖尿病的相关性研究[J].中国现代医学杂志,2017,27(12):55-59,5.
