摘要
Abstract
Objective To evaluate the value of HSP90α, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 (CYFRA21-1) and squamous cell carcinoma antigen (SCCA) in the diagnosis of lung cancer (LC). Methods Patients who were diagnosed as LC were divided into squamous cell carcinoma (LAC) group, adenocarcinoma (LSC) group and small cell carcinoma (SCLC) group. The concentrations of HSP90α, NSE, CEA, CYFRA21-1 and SCCA in blood were analyzed and compared among the 3 groups. Results The levels of HSP90α, CEA, NSE and CYFRA21-1 in the SCLC group were significantly higher than those in the control group (P<0.05). The HSP90α level in the SCLC group was higher than that in the LAC and LSC groups (P<0.05). The levels of HSP90α, NSE, CYFRA21-1 and SCCA in the LAC group were significantly higher than those in the control group (P<0.05). The SCCA level of the LAC group was significantly higher than that of the SCLC and LSC groups (P<0.05). The levels of HSP90α and CEA in the LSC group were significantly higher than that in the control group (P<0.05). The AUC of HSP90α was the highest. The combined detection of HSP90α, NSE and CYFRA21-1 could significantly improve the specificity (SPE), positive predic-tive value (PV+), positive likelihood ratio (LR+) and correct classification rate (CCR) in the diagnosis of SCLC. The combined detection of HSP90α, NSE, CYFRA21-1 and SCCA could significantly improve the SPE, PV+and CCR of LAC, while the combined detection of HSP90α and CEA could significantly improve the SPE, PV+, LR+ and CCR of LSC. Conclusions HSP90 is an ideal index for diagnosis of LC. Combined detection of HSP90α, CEA, NSE, CYFRA21-1 and SCCA contribute to the stratification of lung cancer.关键词
热休克蛋白90α/癌胚抗原/神经元特异性烯醇化酶/细胞角蛋白19片段/鳞状细胞癌抗原/肺癌Key words
heat shock protein 90α/carcinoembryonic antigen/neuron-specific enolase/cytokeratin-19-fragment/squamous cell carcinoma antigen/lung cancer分类
医药卫生
