中国现代医学杂志2017，Vol.27Issue(12)：65-70,6.DOI:10.3969/j.issn.1005-8982.2017.12.013
血管紧张素转化酶基因多态性与妊娠糖尿病的关系
Correlations of ACE gene polymorphism with gestational diabetes mellitus and pregnancy outcome
林玉玲1
作者信息
- 1. 河南省南阳市中心医院 内分泌科,河南 南阳 473000
- 折叠
摘要
Abstract
Objective To investigate the relationships of angiotensin converting enzyme (ACE) gene poly-morphisms with gestational diabetes mellitus (GDM) and pregnancy outcome. Methods Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique was used to analyze ACE insertion (I I) and deletion (D) polymorphism loci in 136 cases of pregnant women with GDM (GDM group), 118 cases of preg-nant women with abnormal glucose tolerance (GIGT group) and 106 pregnant women with normal glucose tolerance (GNGT group). Then the women were followed up, and the correlations between the SNPs of ACE gene and the pregnant outcome were analyzed. Results The frequency of DD genotype and D allele in the GDM group was higher than that in the GNGT group, while the frequency of I I genotype was lower than that in the GNGT group (P<0.05). The FPG, Fins, ACE and HOMA-IR in the GDM patients with ID or DD genotype were significantly higher than those in the GDM patients with I I genotype (P<0.05). The incidences of premature rupture of membranes, premature birth, neonatal respiratory distress syndrome, neonatal hypoglycemia and neonatal hyperbilirubinemia in the GDM women with ID or DD genotype were significantly higher than those in the GDM women with I I genotype (P<0.05). DD genotype and the D allele frequency were the risk factors for GDM (P<0.05). DD genotype was the risk factor for adverse pregnancy outcome (P<0.05). Conclusions DD genotype of single nucleotide polymorphism of ACE (I/D) gene is the independent risk factor for GDM and adverse pregnancy outcome.关键词
妊娠糖尿病/妊娠结局/血管紧张素转化酶/基因多态性Key words
gestational diabetes mellitus/pregnancy outcome/angiotensin converting enzyme/gene polymorphism分类
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林玉玲..血管紧张素转化酶基因多态性与妊娠糖尿病的关系[J].中国现代医学杂志,2017,27(12):65-70,6.
