中国现代医学杂志2017，Vol.27Issue(12)：88-92,5.DOI:10.3969/j.issn.1005-8982.2017.12.018
不同麻醉药物对老年患者术后的影响
Effects of different anesthetic drugs on cognitive function, cerebral oxygen metabolism and neurological function in elderly patients*
摘要
Abstract
Objective To study the effects of different anesthetic drugs on elderly patients. Methods From October 2015 to October 2016, 94 elderly patients undergoing general anesthesia were enrolled. According to the order of admission, the patients were divided into observation group and control group. The observation group was given Etomidate, and the control group was given Propofol. The cognitive function, brain oxygen metabolism and serum neurological improvement were compared between the two groups before operation and 3 days after operation. Results On the 3rd day after operation, the Mini Mental State Examination (MMSE) score of the observation group was significantly higher than that of the control group (P<0.05). The neuron specific enolase of the observation group was significantly lower than that of the control group (P<0.05). The brain-derived neurotrophic factor, insulin-like growth factor 1 and transforming growth factor-β1 in the observation group were significantly higher than those in the control group (P<0.05). Conclusions Etomidate anesthesia in elderly patients can effectively improve the cognitive function of patients, reduce cerebral oxygen metabolism, and play protective effect on patient's brain.关键词
麻醉药物/认知功能/脑部氧代谢/神经功能Key words
anesthetic drugs/cognitive function/brain oxygen metabolism/neurological function分类
医药卫生引用本文复制引用
蔡立松,王蕊,郭平选,韩庆波,席文娟,王太,张辉,刘冰冰..不同麻醉药物对老年患者术后的影响[J].中国现代医学杂志,2017,27(12):88-92,5.基金项目
河北省科学技术厅科技计划项目(No:152777190) （No:152777190）
