中国斜视与小儿眼科杂志2017，Vol.25Issue(2)：26-27,后插6,后插7,4.DOI:10.3969/J.ISSN.1005-328X.2017.02.009
mGluR1在单眼形觉剥夺性弱视大鼠外侧膝状体的表达变化
Expression of mGluR1 at lateral geniculate body of monocular form-deprivation amblyopia rats
刘松涛 1刘向玲2
作者信息
- 1. 454000 焦作市煤业集团中央医院眼一科
- 2. 新乡医学院第三附属医院眼科
- 折叠
摘要
Abstract
Objective To observe the regulation of expression of mGluR1 protein at lateral geniculate body (LGB) of monocular form-deprivation amblyopia rat within sensitve period of visual development, in order to explore its role in the pathogenesis of amblyopia. Methods Rats aged 2 weeks old were randomly divided into normal control group and experimental group, and unilateral eyelid suture was performed on experimental group rats for 30 days and the models of form -deprivation amblyopia were established. We used immunohistochemistry technology to detect the changes of mGluR1 protein expression. Results Compared with normal control group and ipsilateral LGB of deprived eyes group, the expression of mGluR1 protein in contralateral LGB of deprived eyes group are remarkable decreased,and the dif-ferences were significant (P >0.05). There were no significant differences between normal control group and ipsilateral LGB of deprived eyes group ( P>0.05). Conclusions After form-deprivation,the expression of mGluR1 protein is de-pressed in the sensitve period of visual development, which induce the connection of synapses are reduced between neu-rons,then synaptic plasticity changed, and this may be one of the pathogenesis of amblyopia.关键词
形觉剥夺/外侧膝状体/mGluR1Key words
Form-deprivation/Lateralgeniculatebody/mGluR1引用本文复制引用
刘松涛,刘向玲..mGluR1在单眼形觉剥夺性弱视大鼠外侧膝状体的表达变化[J].中国斜视与小儿眼科杂志,2017,25(2):26-27,后插6,后插7,4.
