中国药房2017，Vol.28Issue(17)：2322-2325,4.DOI:10.6039/j.issn.1001-0408.2017.17.05
3种方案治疗A族β溶血性链球菌致急性上呼吸道感染的最小成本分析
Cost-minimization Analysis of 3 Therapeutic Plans for Acute Upper Respiratory Tract Infection Caused by Group Aβ-hemolytic Streptococcus
摘要
Abstract
OBJECTIVE:To evaluate the economical efficiency of 3 therapeutic plans for acute upper respiratory tract infec-tion caused by group A β-hemolytic streptococcal (GAS). METHODS:In retrospective study,71 GAS positive patients with acute upper respiratory tract infection in our hospital during Mar. 2014-Mar. 2016 were selected and divided into group A(16 cases),B(30 cases),C(25 cases)according to medication method. Group A,B,C were given intramuscular injection of ben-zathine benzylpenicillin(1200000 U),oral administration of penicillin V potassium(0.5 g,q8 h,10 d)or oral administration of amoxicillin sulbactam(0.5 g,bid,10 d),respectively. Clinical efficacy and bacterial clearance were observed,and econom-ics of 3 therapeutic plans were evaluated. RESULTS:The cure rates of 3 groups were 87.50%,90.00%,and 92.00%;bacterial clearance rates were 88.24%,87.87%,and 92.59%,respectively;there was no statistical significance(P>0.05). Cost-minimi-zation analysis was adopted for pharmacoeconomic evaluation. The costs of 3 groups were 237.79,279.49,400.40 yuan,respec-tively. The cure rate and bacterial clearance rate of therapeutic plan C were the highest,but its cost also was the highest. The re-sults of sensitivity analysis were consistent with the results of cost-minimization analysis. CONCLUSIONS:The intramuscular in-jection of benzathine benzylpenicillin can be served as first choice therapeutic plan for recurrent upper respiratory tract infection caused by GAS and patients with rhenmatic fever risk. The patients who are reluctant to be treated with penicillin but guarantee medication time can take penicillin V potassium orally. The patients with poor efficacy of common penicillin can take amoxicillin sulbactam pivoxil.关键词
A族β溶血性链球菌/急性上呼吸道感染/青霉素类抗菌药物/最小成本分析/药物经济学Key words
Group Aβ-hemolytic streptococcus/Acute upper respiratory tract infection/Penicillin antibiotics/Cost-minimiza-tion analysis/Pharmacoeconomics分类
医药卫生引用本文复制引用
郑佳昳,李娟,冯立..3种方案治疗A族β溶血性链球菌致急性上呼吸道感染的最小成本分析[J].中国药房,2017,28(17):2322-2325,4.基金项目
西南大学基本科研业务费专项资金项目(No.XDJK 2014C084) （No.XDJK 2014C084）
