中国药理学通报2017，Vol.33Issue(6)：741-744,4.DOI:10.3969/j.issn.1001-1978.2017.06.001
转化生长因子β1在肺动脉高压中作用的研究进展
Research progress on role of TGF-β1 in pulmonary artery hypertension
摘要
Abstract
Pulmonary artery hypertension is a disease with complicated pathogenesis, which is characterized by enhanced pulmonary artery constriction and arterial wall remodeling, leading to progressive increase of pulmonary vascular resistance and pulmonary artery pressure, then resulting in right heart failure.Many studies have shown that transforming growth factor-β1(TGF-β1) plays an important role in the development of various diseases, especially in cardiovascular and cerebrovascular diseases.TGF-β1 is involved in multiple cellular responses including cell proliferation, differentiation, migration and apoptosis.TGF-β1 participates in pulmonary artery hypertension mainly via promoting the proliferation of pulmonary artery smooth muscle cells as well as inducing the deposition of extracellular matrix and endothelial-to-mesenchymal transition(EndMT) through many signaling, which is mainly dominated by pulmonary artery smooth muscle cells and pulmonary artery endothelial cells.This review mainly introduces the role of TGF-β1 in pulmonary artery hypertension in order to provide potential drug targets and therapeutic strategies for pulmonary artery hypertension.关键词
肺动脉高压/TGF-β1/血管重构/肺动脉平滑肌细胞/细胞外基质/肺动脉内皮细胞/内皮间质转化Key words
pulmonary artery hypertension/TGF-β1/vascular remodeling/pulmonary arterial smooth muscle cells/extracellular matrix/pulmonary arterial endothelial cells/endothelial-to-mesenchymal transition分类
医药卫生引用本文复制引用
王丹姝,方莲花,杜冠华..转化生长因子β1在肺动脉高压中作用的研究进展[J].中国药理学通报,2017,33(6):741-744,4.基金项目
国家自然科学基金资助项目(No 81573645,81603101) （No 81573645,81603101）
北京自然科学基金青年科学基金资助项目(No 7174322) （No 7174322）
