中国药理学通报2017，Vol.33Issue(6)：757-760,4.DOI:10.3969/j.issn.1001-1978.2017.06.005
胞外囊泡作为药物传递天然纳米载体的研究进展
The research progress of extracellularvesicles for drug delivery as natural nanocarriers
摘要
Abstract
Phospholipid membrane vesicles from cells play key roles in cell communication, antigen presentation, and transmission of infectious agents.Extracellular vesicles(EVs) carry various proteins, mRNA, and microRNA(miRNA), like a truck to bring different molecular cargoes to remote cells.Furthermore, the encapsulated molecules by EVs can be prevented from being degraded by enzymes in body fluids, making EVs as a natural, novel drug delivery system.In this paper, we review the progress of EVs for biological application and drug delivery vehicles from the classification and composition, which provides a theoretical basis for seeking new drug delivery systems for the treatment of diseases.关键词
胞外囊泡/药物传递/天然纳米载体/免疫治疗/临床实验/研究进展Key words
extracellular vesicles/drug delivery/natural nanocarriers/immunotherapy/clinical trial/research progress分类
医药卫生引用本文复制引用
张欢妍,汪雪峰,马永宾,李莉,舒扬,汪毅..胞外囊泡作为药物传递天然纳米载体的研究进展[J].中国药理学通报,2017,33(6):757-760,4.基金项目
江苏省自然科学基金资助项目(No BK20141295) （No BK20141295）
江苏省"333工程"项目(No BRA2014172) （No BRA2014172）
镇江市社会发展项目(No SH2015033) （No SH2015033）
镇江市重点医学人才 （）
江苏大学附属医院科技项目(No jdfyRC2015010) （No jdfyRC2015010）
江苏省高层次卫生人才"六个一工程"项目(No LGY2016055) （No LGY2016055）
