内科2017，Vol.12Issue(3)：297-300,4.DOI:10.16121/j.cnki.cn45-1347/r.2017.03.01
慢性阻塞性肺疾病患者Gc基因多态性与游离态25-羟维生素D的关系研究
Relationship between Gc gene polymorphism and the free 25-hydroxyvitamin D in patients with chronic obstructive pulmonary disease
摘要
Abstract
Objective To explore the relationship between Gc gene polymorphism and free 25-hydroxyvitamin D in patients with chronic obstructive pulmonary disease.Methods A total of 120 smokers with COPD (COPD group) and 107 smokers with non COPD (non COPD group) were enrolled as the research objects, the levels of serum total 25-hydroxyvitamin D, VDBP and albumin of all the subjects were measured, Gc gene polymorphism analysis was performed, and the level of free 25-hydroxyvitamin D in different Gc genotype subjects were analyzed.Results The FEV1、FEV1/FVC in patients with COPD were significantly lower than those in objects with non COPD, scores of CAT in patients with COPD were significantly higher than those in objects with non COPD, 6-minute walk distance in patients with COPD were significantly shorter than that in objects with non COPD (P<0.05).The levels of total and free 25-hydroxyvitamin D in patients with COPD were significantly lower than those in objects with non COPD, and the level of ADBP in patients with COPD was significantly higher than that in objects with non COPD (P<0.05).The frequency of 1F-1F genotype of Gc gene in patients with COPD was significantly higher than that in objects with non COPD, and the frequency of 2-2 genotype of Gc gene in patients with COPD was significantly lower than that in objects with non COPD (P<0.05);no statistical significance was found between patients with COPD and objects with non COPD in the frequency of 1F-1S,1F-2,1S-2,1S-1S genotype of Gc gene (P>0.05).There was significant difference in the level of free 25-hydroxyvitamin D among difference genotype of Gc gene in patients with COPD and objects with non COPD (P<0.05);the levels of free 25-hydroxyvitamin D of 1F-1F genotype in patients with COPD and objects with non COPD were significantly lower than those of others genotype (P<0.05);and the levels of free 25-hydroxyvitamin D of 2-2 genotype in patients with COPD and objects with non COPD were significantly higher than those of others genotype (P<0.05).There was significant difference in the levels of free 25-hydroxyvitamin D between 1F-1F and 2-2 genotype in patients with COPD and objects with non COPD (P<0.05).Conclusions Patients with COPD has lower levels of free 25-hydroxyvitamin D, there is differences in free 25-hydroxyvitamin D among different Gc genotypes patients with COPD, Gc gene may participate in the genesis of COPD by regulating the level of 25-hydroxyvitamin D, and the detection of free 25-hydroxyvitamin D may be more valuable than the simple determination of total vitamin D.关键词
慢性阻塞性肺疾病/游离态25-羟维生素D/Gc基因/基因多态性/维生素D结合蛋白Key words
Chronic obstructive pulmonary disease/Free 25-hydroxyvitamin D/Gc gene/Gene polymorphisms/ADBP分类
医药卫生引用本文复制引用
周燕宁,黄河,彭丽慈,黄晓霞,施睿,张敏..慢性阻塞性肺疾病患者Gc基因多态性与游离态25-羟维生素D的关系研究[J].内科,2017,12(3):297-300,4.基金项目
2014年深圳市科技计划项目 (JCYJ20140414170821283) （JCYJ20140414170821283）
