摘要
Abstract
Objective To investigate the effect of early hyperbaric oxygen therapy on CRP、NO、Bcl-2 in patients with cerebral ischemia/reperfusion injury.Methods A total of 85 patients with cerebral ischemia/reperfusion injury treated in our hospital were enrolled as the research objects, all patients received early hyperbaric oxygen therapy on the basis of conventional therapy, cerebral blood volume (CBV), cerebral blood flow (CBF), cerebral blood mean transit time (MTT) of patients were observed before treatment, at 1 day, 7 days, 14 days after treatment, the level of CRP, NO, Bcl-2 and blood lactic acid were also detected.Results With the duration of treatment, MTT decreased significantly;CBV, CBF increased significantly, and CBV, CBF were up to the peak at 7 days after treatment, there was significant difference in blood flow index among different treatment time (P<0.05);with the duration of treatment, the levels of CRP and blood lactic acid were gradually decreased, while the levels of NO, Bcl-2 were gradually increased, there was significant difference in the levels of CRP, NO, Bcl-2, blood lactic acid among different treatment time (P<0.05).Conclusions Hyperbaric oxygen therapy can alleviate cerebral perfusion injury, protect nerve by improving microcirculation, regulating the level of Bcl-2, reducing inflammation and stress response.关键词
缺血再灌注损伤/治疗/高压氧/血清炎性因子/一氧化氮/抗凋亡蛋白/乳酸Key words
Ischemia/reperfusion injury/Treatment/Hyperbaric oxygen/Serum inflammatory factors/NO/Bcl-2/Blood lactic acid分类
医药卫生
