中国药业2017，Vol.26Issue(9)：38-40,3.DOI:10.3969/j.issn.1006-4931.2017.09.012
吉非替尼联合简化调强放疗技术治疗非小细胞肺癌临床研究
Clinical Study of Gefitinib Combined with Simplified Intensity Modulated Radiotherapy in Treating Non-Small Cell Lung Cancer
胡洪林1
作者信息
- 1. 四川省人民医院肿瘤科,四川成都 610072
- 折叠
摘要
Abstract
Objective To investigate the clinical effect of Gefitinib combined with simplified intensity modulated radiotherapy ( sIMRT ) in treating non-small cell lung cancer ( NSCLC ) . Methods Totally 120 patients with NSCLC from January 2010 to December 2013 in our hospital were randomly divided into the observation group and the control group. 60 cases in each group. The two groups were given sIMRT treatment. on this basis. the observation group added Gefitinib targeted therapy. Results The effective rate in the observation group was 75. 00%. which was significantly higher than 56. 67% in the control group ( P < 0. 05 ) . After treatment. the EGFR. SCC. CEA and CA125 in the observation group were significantly lower than those in the control group ( P < 0. 05 ) . The incidence rate of bone marrow suppression. gastrointestinal adverse reactions. skin adverse reactions and liver and kidney function lesion in the two group had no significance difference ( P > 0. 05 ) . The PFS and OS in the observation group were significantly longer than those in the control group ( P < 0. 05 ) . Conclusion Gefitinib combined with sIMRT for treating NSCLC has good effect. and the patients have long survival time and few adverse reactions. It is worthy of clinical promotion.关键词
吉非替尼/简化调强放疗/非小细胞肺癌/临床疗效Key words
Gefitinib/simplified intensity modulated radiotherapy/non-small cell lung cancer/clinical effect分类
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胡洪林..吉非替尼联合简化调强放疗技术治疗非小细胞肺癌临床研究[J].中国药业,2017,26(9):38-40,3.
