摘要
Abstract
Objective To investigate the effect of Atorvastatin on oxidative stress and lipid peroxidation in elderly patients with ischemic stroke. Methods Totally 108 elderly patients with ischemic stroke in the hospital from June 2015 to July 2016 were randomly divided into two groups,54 cases in each group. The control group was treated with Aspirin and other drugs,and the study group was treated with Atorvastatin on the basis of the control group. The treatment effect of ischemic stroke,the levels of HDL-C,LDL-C,TG,TC, OX-LDL and plasma 8-isoprostanes F2α,the incidence of adverse reactions in the two groups were compared. Results The total ef-fective rate of the study group of was significantly higher than that of the control group(P < 0. 05). Before treatment,the levels of HDL-C,LDL-C,TG,TC in the two groups had no significant difference(P > 0. 05),after treatment,the indexes in the two groups significantly improved,and the study group improved more obviously(P < 0. 05). Before treatment,the levels of OX-LDL and plasma 8-isoprostanes F2α in the two groups had no significant difference(P > 0. 05),after treatment,the indexes in the control group signifi-cantly increased,and the control group increased more obviously than the study group (P < 0. 05). There was no obvious adverse reac-tions in the two groups(P > 0. 05). Conclusion Atorvastatin in the treatment of elderly patients with ischemic stroke has great effect on the peroxidation of oxidative stress and lipid,it can effectively improve blood lipid levels,lipid peroxidation and anti-oxidative stress,promote the improvement of clinical symptoms and prognosis of patients,which is worthy of clinical promotion.关键词
阿托伐他汀/老年/缺血性脑卒中/氧化应激/脂质过氧化Key words
Atorvastatin/elderly/ischemic stroke/oxidative stress/lipid peroxidation分类
医药卫生
