摘要
Abstract
Objective To investigate the influence of Tanshinone ⅡA Sulfonate Sodium Injection on platelet activation function in patients with unstable angina ( UA ) pectoris of coronary atherosclerotic heart disease with blood stasis syndrome. Methods Totally 80 patients with unstable angina pectoris of coronary atherosclerotic heart disease patients with blood stasis syndrome admitted to our hospita from January 2013 to August 2016 were randomly divided into two groups by single blind randomized grouping method,40 cases in each group. The control group was treated with western medicine alone,on this basis,the observation group was added Tanshinone ⅡA Sul-fonate Sodium Injection. After 2 weeks of treatment,the clinical total effective rate,angina attack frequency and quality of life score, platelet membrane surface glycoprotein expression were compared between the two groups. Results The total effective rate in the obser-vation group was 95. 00%,which was significantly higher than 80. 00% in the control group (P < 0. 05). After treatment,the anginal attacks in the two groups were significantly decreased(P < 0. 05),and the observation group decreased more obviously(P < 0. 05). The life quality scores in the observation group was significantly higher than that in the control group(P < 0. 05). Compared with before treatment,the expression level of platelet membrane glycoprotein CD63 and PAC-1 were significantly increased in the two groups after treatment(P < 0. 05),the expression level of CD42b after treatment was significantly decreased(P < 0. 05),and the expression level of platelet membrane glycoprotein in the two groups had significant difference(P < 0. 05). Conclusion Tanshinone ⅡA Sulfonate Sodium Injection in the treatment of unstable angina pectoris of coronary atherosclerotic heart disease patients with blood stasis syndrome has significant clinical efficacy,it can relieve angina symptoms,improve quality of life,inhibit the activation of platelet function,and it is good for improving prognosis.关键词
冠状动脉粥样硬化性心脏病/不稳定型心绞痛/血瘀证/丹参酮ⅡA磺酸钠注射液/血小板活化功能Key words
coronary atherosclerotic heart disease/unstable angina/blood stasis syndrome/Tanshinone ⅡA Sulfonate Sodium Injection/platelet activation function分类
医药卫生
