摘要
Abstract
Objective To investigate the effects of Irbesartan combined with Atorvastatin on renal function recovery and serum gly-cosylated hemoglobin (HbA1C),cystatin C(CysC) and fibrinogen (Fib) levels in patients with early diabetic nephropathy(DN). Methods Totally 77 patients with early DN from September 2014 to May 2016 in our hospital were divided into the control group (n=38)and the study group(n=39)according to the file order,the control group was treated with Irbesartan,while the study group was treated with Irbesartan and Atorvastatin,both groups were treated for 6 months. Serum HbA1C,CysC,Fib levels were statistically ana-lyzed between the two groups before and after treatment,and the renal function indicators (BUN,β2-MG,SCr) levels were compared between the two groups. Results There were no significant differences in serum BUN,β2-MG and SCr levels between the two groups before treatment (P > 0. 05),but after treatment,the study group was significantly lower than the control group(P < 0. 05);There was no significant difference in serum HbA1C,CysC and Fib levels between the two groups before treatment(P > 0. 05),but after treatment, the study group was significantly lower than the control group(P < 0. 05). Conclusion Irbesartan combined with Atorvastatin for treat-ing early DN can effectively promote the recovery of renal function,improve the serum HbA1C,CysC and Fib levels.关键词
厄贝沙坦/阿托伐他汀/早期糖尿病肾病/糖化血红蛋白/胱抑素CKey words
Irbesartan/Atorvastatin/early diabetic nephropathy/HbA1C/CysC分类
医药卫生
