中国中西医结合外科杂志2017，Vol.23Issue(3)：287-291,5.DOI:10.3969/j.issn.1007-6948.2017.03.017
金银花配方颗粒的质量标准研究
Study on Quality Standard of Honeysuckle Formula Granules
摘要
Abstract
Objective To establish a quality control method and provide a reference basis on the quality control of Honeysuckle Formula Granules through the means of High Performance Liquid Chromatography (HPLC) and Fourier Transform Infrared Spectrometer(FTIR). Methods Honeysuckle Formula Granules from different pharmaceutical companies were scanned by FTIR, and the contents of chlorogenic acid was determined by HPLC. Comparing the infrared spectrogram with the contrast medicinal materials and research the same peak position and peak intensity of absorption peak among them. Results In the range of 0.008~0.04 g/L , the peak area and the concentration of chlorogenic acid had a good linear, r=0.9998. In Honeysuckle Formula Granules from 6 manufacturers namely A, B, C, D, E, F, the content of chlorogenic acid were 4.00%, 3.98%, 2.81%, 3.98%, 2.62% and 2.23%, respectively. The IR spectra of Honeysuckle Granules of six different produc-ers were different, because of using different excipients, mainly starch and sucrose;the peak indicators of Honey-suckle Formula Granules is 1692 cm-1, 1606 cm-1, 1522 cm-1, 817 cm-1 and 602 cm-1. Conclusion The con-tent of chlorogenic acid and the height of the peak exist differences in Honeysuckle Formula Granules from dif-ferent enterprises. Detecting the varieties and proportion of materials added in Honeysuckle Formula Granules by FTIR could eliminate the interference of auxiliary materials to the quality control method.关键词
金银花配方颗粒/高效液相色谱法/傅里叶变换红外光谱法/质量标准Key words
Honeysuckle formula granules/high performance liquid chromatography/fourier transform in-frared spectrometer/ouality standard分类
医药卫生引用本文复制引用
夏亚飞,阎姝,杨艳..金银花配方颗粒的质量标准研究[J].中国中西医结合外科杂志,2017,23(3):287-291,5.基金项目
天津市中医药管理局中医中西医结合基金资助项目(13038) （13038）
