中成药2017，Vol.39Issue(6)：1109-1114,6.DOI:10.3969/j.issn.1001-1528.2017.06.001
黄芪散对糖皮质激素性骨质疏松大鼠股骨和胫骨的影响
Effects of Huangqi Powder on femur and tibia in rats with glucocorticoid-induced osteoporosis
摘要
Abstract
AIM To study the influence of Huangqi Powder (Puerariae lobatae Radix,Astragali Radix,Mori Cortex) on femur and tibia in rats with glucocorticoid-induced osteoporosis (GIOP).METHODS Thirty one-month-old male SD rats were divided into three groups by randomized block design,which were control group (normal saline),prednisone group (3.5 mg/kg prednisone acetate),Huangqi Powder group (clinical adult dosage).Experimental test was maintained for one hundred and twenty days.Double fluorochrome labeling with calcein was performed before necropsy;bone resorption and bone formation index were determined by using blood serum;the femur structural and material mechanics were analyzed by using bone biomechanics method.The cancellous bone of proximal tibial and the cortical bone of tibial shaft static parameter and dynamic parameter were analyzed by bone histomorphometry method.RESULTS Huangqi Powder had no obvious improving effects on bone biomechanics and bone static parameter,but could increas the area,width and number of the proximal tibia bone trabecular.Mark perimeter percentage and mineralization rate of deposition could be increased.CONCLUSION Huangqi Powder can significantly increase proximal tibia cancellous bone mass and enhance bone trabecula structure of glucocorticoid-induced osteoporosis rats.关键词
糖皮质激素性骨质疏松/黄芪散/骨生物力学/骨组织形态计量学/股骨/胫骨Key words
glucocorticoid-induced osteoporosis/Huangqi Powder (HQP)/bone biomechanics/bone histomorphometry/femur/tibia分类
医药卫生引用本文复制引用
王芳,陈珺,曾煦欣,张家豪,梁丹丹,李卫民..黄芪散对糖皮质激素性骨质疏松大鼠股骨和胫骨的影响[J].中成药,2017,39(6):1109-1114,6.基金项目
国家自然科学基金面上资助项目(81473439) （81473439）
2017年广东省普通高校青年创新人才项目(2017) （2017）
