中成药2017，Vol.39Issue(6)：1115-1119,5.DOI:10.3969/j.issn.1001-1528.2017.06.002
没食子酸对谷氨酸钠诱导的肥胖小鼠的降脂作用
Lipid-lowering effects of gallic acid on glutamate-induced obese mice
摘要
Abstract
AIM To study lipid-lowering effects of gallic acid on glutamate-induced obesity mice.METHODS The obese model was established through subcutaneous injection of 3mg/(g · d)sodium glutamate into neonatal mice.After the model was established,the mice were divided into normal control group,model group,positive control group [simvastatin 30 mg/(kg · d)],high-,and low-dose group of gallic acid [400,200 mg/(kg · d)],and were intragastrically administered for ten weeks.Mice in each group after the last administration were fasted for 12 h except water.Blood was sampled from mouse eyes.The organs and adipose were obtained to determine the organ index and fat index.The levels of HDL-C,TG,LDL-C and TC in serum and liver were determined by using the corresponding reagent kit,and the serum leptin level was determined by ELISA kit and simultaneous determination of SOD,GSH-Px and MDA levels in liver.RESULTS Compared with the normal control group,the body weight and fat weight significantly increased in the model group;the levels of TC,TG and LDL-C in serum and liver significantly increased;the serum leptin level significantly reduced;the activity levels of SOD and GSH-Px in the liver significantly reduced;and the level of MDA significantly increased.Compared with the model control group,the body weight and fat weight significantly reduced in the gallic acid group mice and the levels of TC and TG significantly reduced in the serum and liver;SOD and GSH-Px levels significantly increased,MDA level significantly decreased in the liver.CONCLUSION Gallic acid can significantly reduce the blood lipid level of glutamate-induced obese mice.关键词
没食子酸/谷氨酸钠/肥胖小鼠/降脂Key words
gallic acid/monosodium glutamate/obesity mice/lipid-lowering effect分类
医药卫生引用本文复制引用
张旭,陈朝银,董珺琳,蔡金燕,赵声兰..没食子酸对谷氨酸钠诱导的肥胖小鼠的降脂作用[J].中成药,2017,39(6):1115-1119,5.基金项目
国家自然科学基金(21466037) （21466037）
云南省教育厅重大专项(ZD2014009) （ZD2014009）
云南省应用基础研究-中医联合专项(U0120150242) （U0120150242）
