中成药2017，Vol.39Issue(6)：1134-1138,5.DOI:10.3969/j.issn.1001-1528.2017.06.005
青钱柳叶对糖尿病大鼠的治疗作用
Therapeutic effects of leaf extract from Cyclocarya paliurus on rats with type 2 diabetes mellitus
摘要
Abstract
AIM To speculate the hypoglycemic mechanism for rats with type 2 diabetes by exploring the therapeutic effects of leaf aqueous extract from Cyclocarya paliurus on liver insulin receptor (InsR) and insulin receptor substrate 2 (IRS-2).METHODS The diabetic rat model was established through intraperitoneal injection of streptozotocin and fed with high-fat diet.The moleled rats were equally assigned into the control group and leaf aqueous extract from Cyclocarya paliurus group (extract group).After the test extract was orally administrated for four weeks,body weight,urine output,food intake,water intake and fasting blood-glucose (FBG) were measured,and the levels of serum insulin,InsR and IRS-2 mRNA in liver tissue were investigated in rats.RESULTS Compared with the control group,the extract group showed a reduction in urine output,food intake,water intake,FBG and insulin levels.Meanwhile,the rats' body weights in extract group were presented a trend to increase.The gene expressions of InsR and IRS-2 in liver tissue were up-regulated.Moreover,the insulin sensitivity was improved.CONCLUSION The leaf aqueous extract from Cyclocarya paliurus can reduce FBS,improve insulin sensitivity,which may be associated with the increase of InsR and IRS-2 gene expression in liver tissue.关键词
青钱柳(Cyclocarya paliurus)/叶水提物/2型糖尿病/胰岛素敏感性Key words
Cyclocarya Paliurus/leaf aqueous extract/type 2 diabetes mellitus/insulin sensitivity分类
医药卫生引用本文复制引用
扶丽君,操红缨,胡明华,尹西拳,连大卫,任文康,许艺飞,范平龙,陈娅琦,蔡泳锋..青钱柳叶对糖尿病大鼠的治疗作用[J].中成药,2017,39(6):1134-1138,5.基金项目
广州中医药大学中药学院高水平大学建设项目(2013) （2013）
