中成药2017，Vol.39Issue(6)：1139-1144,6.DOI:10.3969/j.issn.1001-1528.2017.06.006
开心解郁丸对血管性抑郁大鼠单胺递质及BDNF的影响
Effects of Kaixin Jieyu Pills on monoamines and BDNF in rats with vascular depression
摘要
Abstract
AIM To aim at investigating the function of Kaixin Jieyu Pills (Ginseng Radix et Rhizoma,Bupleuri Radix,Morindae officinalis Radix,etc.) to vascular depression and their mechanism of action.METHODS A vascular depression model of rat was established by chronic unpredictable mild stress and separation after ligation of the bilateral common carotid arteries.The rats were treated with Kaixin Jieyu Pills and fluoxetine hydrochloride (FLU) for 28 days,respectively.The sucrose preference test and open-field test were performed.Cerebral perfusion was investigated with a Perfusion Speckle Imager.The monoamines including serotonin,dopamine and noradrenaline,and brain-derived neurotrophic factor (BDNF) were determined with ELISA and Western bolt,respectively.RESULTS Kaixin Jieyu Pills significantly increased sucrose preference,moving distance and cortical blood flow.Kaixin Jieyu Pills could upregulate,to different extents,the expressions of monoamines,including serotonin,noradrenaline and dopamine,and BDNF.Kaixin Jieyu Pills had a function similar to FLU in behavior,upregulating monoamines and BDNF,but it is superior to FLU in cortical blood flow.CONCLUSION Kaixin Jieyu Pills has the advantage of reducing the depression-like behavior and improving cerebral hypoperfusion,which might be mediated by the upregulation of the serotonin,noradrenaline and BDNF.关键词
开心解郁丸/血管性抑郁/单胺递质/脑源性神经营养因子/脑血流Key words
Kaixin Jieyu Pills/vascular depression/monoamine/brain-derived neurotrophic factor (BDNF)/cerebral perfusion分类
医药卫生引用本文复制引用
潘菊华,王彦云,李多娇,郑军,陈宇霞,黄世敬..开心解郁丸对血管性抑郁大鼠单胺递质及BDNF的影响[J].中成药,2017,39(6):1139-1144,6.基金项目
国家自然科学基金项目(81573790,81603443) （81573790,81603443）
北京市中医药科技发展资金项目(JJ2015-52) （JJ2015-52）
北京市科技计划“十病十药”研发专项(Z14110000224014) （Z14110000224014）
