中成药2017，Vol.39Issue(6)：1149-1156,8.DOI:10.3969/j.issn.1001-1528.2017.06.008
清开灵注射液治疗病毒性肝炎引起肝功能异常的Meta分析
Meta-analysis of Qingkailing Injection in treatment of viral hepatitis
摘要
Abstract
AIM The proofs of evidence-based medicine of Qingkailing Injection's effect on viral hepatitis are lack in spite of the wide use of Qingkailing Injection in medical practice.This study aims to use Meta-analysis to evaluate its clinical effect and safety.METHODS Such databases as CNKI,VIP and Wanfang were searched for randomized controlled trials related to Qingkailing Injection in treatment of viral hepatitis,which were published officially between 1996--2016.Revman 5.3 software was used to conduct Meta-analysis for the effective rate,rate of adverse reaction,the decrease rate of ALT,AST and TBIL of Qingkailing Injection.Meanwhile,subgroup analysis was conducted to the clinical effect of doses [＜ 0.5 mL/(kg · d),0.5-0.67 mL/(kg · d),＞0.67 mL/(kg · d)],treatment courses (≤ 14 d,＞ 14 d),manufacturers (Beijing University of Chinese Medicine Pharmaceutical Factory,Shenwei Pharmaceutical Company,Shanxi Taihang Pharmaceutical Company),year (1996 to 2002,2003 to 2009,2010 to 2016).RESULTS Fourteen studies were included according to the criterion.The results of Meta-analysis showed that the total effective rate,the decrease rate of ALT,AST and TBIL in Qingkailing Injection group were significantly higher than those in the control group (P ＜ 0.05).Whereas,no significiant differences were found between Qingkailing Injection group and the control group of its rate of adverse reaction (P ＞ 0.05).Subgroup-analysis showed that the effective rate of Qingkailing in doses subgroup,treatment courses subgroup,manufacturers subgroup and year subgroup were significantly higher than those of the control group.CONCLUSION Qingkailing Injection has obvious benefit in the treatment of viral hepatitis,which can reduce the activity of ALT and AST,also can reduce the content of TBIL.But we should pay attention to the prevention of allergic reaction in the clinical use.关键词
清开灵注射液/有效率/Meta分析/不良反应Key words
Qingkailing Injection/effective rate/Meta-analysis/adverse reaction分类
医药卫生引用本文复制引用
王茜,谢家骏,胡风丽,杨艺帆,陈锰..清开灵注射液治疗病毒性肝炎引起肝功能异常的Meta分析[J].中成药,2017,39(6):1149-1156,8.基金项目
国家“十二五”科技重大专项课题(2011ZX09301-009) （2011ZX09301-009）
