中成药2017，Vol.39Issue(6)：1156-1160,5.DOI:10.3969/j.issn.1001-1528.2017.06.009
西黄胶囊防治急性放射性口腔黏膜炎的疗效及相关机制
The protection of Xihuang Capsules against acute radiation-induced oral mucositis and its mechanisms
摘要
Abstract
AIM To explore the radioprotective function of Xihuang Capsules (Bovis Calculus artijactus,Moschus,Olibanum,Myrrha) in patients with acute radiation-induced oral mucositis and its mechanisms.METHODS Eighty patients with nasopharyngeal carcinoma undergone radiotherapy were randomized into two groups:treatment group (radiation plus Xihuang Capsules) and control group (radiation alone).The comparison of two groups in the onset and the tolerated dose of mucositis was made according to the acute radiation injury classification standard.The levels of TNF-α and IL-6 in saliva were detected by ELISA.RESULTS After the treatment with Xihuang Capsules,the onset of oral mucositis delayed significantly and the tolerated dose elevated markedly comparing with the control group (t =2.180,12.930,P ＜ 0.05).The morbidity rate of Ⅲ-N-degree of oral mucositis in the treatment group was lower than that of the control group at the dosage of 40 Gy and 70 Gy,respectively (Z =3.661,4.270,P ＜0.01).Furthermore,there was no difference in the levels of TNF-α and IL-6 in the pre-treatment in the two groups (t =1.010,1.469,P ＞ 0.05).With the increase in radiant dose,the levels of TNF-α and IL-6 in the two groups both elevated dramatically,and peaked at the dose of 40 Gy,but both levels in the treatment group were lower than those of the control group (t =8.305,6.069,P ＜ 0.05).When DT =70 Gy,the levels of TNF-α and IL-6 were lower than pre-radiation,and the levels of TNF-α and IL-6 in the treatment group were lower than those in the radiation alone group (t =3.835,2.488,P ＜ 0.05).CONCLUSION Xihuang Capsules can delay and reduce acute radiation-induced oral mucositis and improve radiation tolerated dose,so it may involve the release of TNF-oα and IL-6 in saliva.关键词
西黄胶囊/放射性口腔黏膜炎/TNF-α/IL-6Key words
Xihuang Capsules/radiation-induced oral mucositis/TNF-α/IL-6分类
医药卫生引用本文复制引用
董克臣,夏林,梁毅,靳光华,朱琳燕..西黄胶囊防治急性放射性口腔黏膜炎的疗效及相关机制[J].中成药,2017,39(6):1156-1160,5.基金项目
湖北省自然科学基金(2013CFC060) （2013CFC060）
