中成药2017，Vol.39Issue(6)：1161-1164,4.DOI:10.3969/j.issn.1001-1528.2017.06.010
碳纳米管结合人参皂苷Rb1、Rb2纳米乳经皮给药系统的制备
Preparation of transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2 nanoemulsion
摘要
Abstract
AIM To prepare the transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2 nanoemulsion.METHODS After 0.5％ carbon nanotubes' dispersion into the prepared nanoemulsion,the combination state was observed under transmission electron microscope.The skin irritation and transdermal mechanism of this drug delivery system were investigated.Then the UVA-damaged mouse skin model was established to evaluate the antioxidant activity.RESULTS Carbon nanotubes had strong adsorption to nanoemulsion,together with the formation of drug storage cavern in epidermis,thus increased the transdermal osmotic quantities of ginsenosides Rb1 and Rb2.The SOD activity in mouse skin tissue in the drug delivery system group was higher than that in the model group and the nanoemulsion group (P ＜0.01),and the MDA content was significantly decreased (P ＜ 0.01).CONCLUSION The transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2 nanoemulsion can make drugs play an antioxidant role because of its less irritation to skin and better skin permeability.关键词
碳纳米管/人参皂苷Rb1/人参皂苷Rb2/纳米乳/经皮给药系统/抗氧化活性Key words
carbon nanotubes/ginsenoside Rb1/ginsenoside Rb2/nanoemulsion/transdermal drug delivery system/antioxidant activity分类
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曾臣红,王政,陈冲,魏莉..碳纳米管结合人参皂苷Rb1、Rb2纳米乳经皮给药系统的制备[J].中成药,2017,39(6):1161-1164,4.
