广东海洋大学学报2017，Vol.37Issue(3)：86-92,7.DOI:10.3969/j.issn.1673-9159.2017.03.013
Fat-1转基因模型小鼠对脂多糖诱导的抑郁样行为和中枢炎症反应的改善作用
Improvement of Fat-1 Transgenic Mice on the Depression Behavior and Inflammatory Response Induced by LPS
摘要
Abstract
The wild type C57BL/6 mice and transgenic mice Fat-1 are used as the research objects. After 24 h central administration of lipopolysaccharide (LPS) and saline, sucrose preference, immobility times of tail suspension test, activity and phagocytosis of macrophages, CD11b gene and protein expression level were measured to study the potential anti-inflammatory effect of n-3 polyunsaturated fatty acids produced in the brain. The results showed that after LPS was injected to the C57BL/6 mice, the sucrose preference was significantly decreased (P < 0.05), the tail suspension immobility time was significantly increased (P < 0.01), the activity of peritoneal macrophages (P < 0.01) and phagocytosis (P< 0.05) significantly increased, CD11b gene (P < 0.01) and protein expression level (P < 0.05) increased significantly, while LPS-induced change was reversed in Fat-1 mice. It can be seen that the injection of LPS to lateral ventricle can cause depression like symptoms in mice, while Fat-1 mice can improve the depression like symptoms induced by LPS producing n-3 PUFAs in the brain and the body.关键词
抑郁症/Fat-1小鼠/LPS/炎症/n-3多不饱和脂肪酸Key words
depression/Fat-1 mice/LPS/inflammatory/n-3 PUFAs分类
医药卫生引用本文复制引用
刘白平,李玉玉,张才,薛红莎,张永平,赵云涛,卢虹玉,宋采..Fat-1转基因模型小鼠对脂多糖诱导的抑郁样行为和中枢炎症反应的改善作用[J].广东海洋大学学报,2017,37(3):86-92,7.基金项目
国家自然科学基金(81171118,81471223) （81171118,81471223）
湛江市科技攻关计划项目"脑健康海洋药物与营养品重点实验室" （）
