中药材2016，Vol.39Issue(12)：2811-2814,4.DOI:10.13863/j.issn1001-4454.2016.12.032
Box-Behnken效应面法优选斑蝥超微粉碎工艺
Optimization of Ultrafine Grinding Technology for Mylabris phalerata by Box-Behnken Design-Response Surface Methodology
摘要
Abstract
Objective:To optimize ultrafine grinding process of Mylabris phalerata.Methods:The Box-Behnken design-response surface methodology was adopted to optimize ultrafine grinding process of Mylabris phalerata with moisture content,grinding time and medium as investigate factors,the overall desirability(OD) of cantharidin content and powder particle size Dg0 as indexes,and the cantharidin content before and after smashed was investigated.Results:The optimization ultrafine grinding process was as follows,the moisture content was 6％,rinding time was 17 min,medium was 70％;the cantharidin content before and after were 0.3905％,0.4885％,respectively.Conclusion:This optimized ultrafine grinding process proves to be reasonable and good predictability by Box-Behnken design-response surface methodology and the overall desirability,and it can provides reference for grinding process of Mylabris phalerata.关键词
斑蝥/超微粉碎工艺/Box-Behnken效应面法/总评归一值/斑蝥素/粉体粒径Key words
Mylabris/Ultrafine grinding process/Box-Behnken design-response surface methodology/Overall desirability/Cantharidin/Powder particle size分类
医药卫生引用本文复制引用
李跃辉,王银,何杰,谭丽,黄江波,张水寒,唐正平..Box-Behnken效应面法优选斑蝥超微粉碎工艺[J].中药材,2016,39(12):2811-2814,4.基金项目
国家中医药管理局中医药行业科研课题(200807054) （200807054）
湖南省自然科学基金(C190710) （C190710）
