吉林大学学报（医学版）2017，Vol.43Issue(2)：276-280,后插1-后插2,7.DOI:10.13481/j.1671-587x.20170213
PLGA涂层处理的nHA-Mg多孔复合材料对兔颌骨缺损的修复作用
Repair effect of nHA-Mg porous composite materials modified by PLGA on jaw bone defect of rabbits
摘要
Abstract
Objective:To observe the repair effect of nano hydroxyapatite/magnesium(nHA-Mg)porous composite material modified by poly lactic acid/glycolic acid copolymer(PLGA) on the jaw bone defect of rabbits,and to elucidate the mechanisms preliminary.Methods:The mandibular defect models of 10 mm×5 mm×1 mm in the 18 rabbits were established.Nine rabbits were selected and implanted with nHA-Mg composite materials modified by PLGA in the left as experimental group and the right as blank control group;the other nine were implanted with nHA-Mg in the left as positive control group and the right as blank control group.The rabbits were sacrificed at 4, 8, 12 weeks (respectively 3 of experimental group and positive control group every time)and the mandibular defect areas were intercepted and observed by imaging and histological examination;the sizes of the newborn trabecula area and residual materials in experimental group and positive control group were compared.Results:Compared with positive control group and blank control group, the percentage of newborn trabecula area of the rabbits in experimental group was increased (P<0.05),and there was no statistic difference between positive control group and blank control group (P>0.05).The imaging results showed that the new bone formation can be observed in experimental group and better than positive control group and blank control group.The paraffin section results indicated that there were visible vascular tissue and newborn trabecula,the osteoblasts gathered around the bone trabecula;a lot of pits were located in the bone trabecula, and the pits contained osteocytes in experimental group.As the prolongation of time,thickened newborn trabecula, dense arrangement and trend of converting to lamellar bone were observed in experimental group.The hard tissue section results showed that the remaining amount of materials in experimental group was more than that in positive control group.Conclusion:nHA-Mg porous composite materials modified by PLGA can effectively reduce the rate of degradation in the body, promote osteogenesis and guide the bone regeneration.关键词
纳米羟基磷灰石/镁/聚乳酸-羟基乙酸共聚物/颌骨缺损Key words
nano-hydroxyapatite/magnesium/poly lactic acid/glycolic acid/jaw bone defect分类
医药卫生引用本文复制引用
车鸿泽,车彦海,卢晴,陈楠楠,陈飞,金权,马宁..PLGA涂层处理的nHA-Mg多孔复合材料对兔颌骨缺损的修复作用[J].吉林大学学报（医学版）,2017,43(2):276-280,后插1-后插2,7.基金项目
吉林省发改委产业技术研究与开发项目资助课题(2013C022-5) （2013C022-5）
