吉林大学学报（医学版）2017，Vol.43Issue(2)：353-355,后插2,4.DOI:10.13481/j.1671-587x.20170227
p16INK4a蛋白在蒙古族患者宫颈病变组织中的表达及其意义
Expressions of p16INK4a protein in cervical lesion tissues of Mongolian patients and their significances
摘要
Abstract
Objective:To detect the expressions of p16INK4a protein in the cervical lesion tissues of the Mongolian patients, and to explore the relationship between its expression and the occurrence and development of cervical cancer in the Mongolian patients.Methods:A total of 100 cases of paraffin sections of cervical cancer, cervical intraepithelial neoplasia(CIN),chronic cervicitis and uterine leiomyoma were divided into 25 cases of cervical cancer, 35 cases of CIN, 20 cases of chronic cervicitis, and 20 cases of uterine leiomyoma groups. The expressions of p16INK4a protein in different cervical tissues were detected by immunohistochemical SP method.Results:The positive rates of p16INK4a protern in cervical cancer, CIN, chronic cervicitis and uterine leiomyoma tissnes were 100.0%, 74.3%, 25.0%,and 10.0%, respectively.The results of K-W H rank sum test for multiple sample comparisons showed that the positive expression rate of p16INK4a protein in cervical cancer tissue was significantly higher than those in CIN, chronic cervicitis and uterine leiomyoma tissues(P<0.05).Conclusion:p16INK4a protein can be used as a indicator to screen the Mongolian patients with early cervical cancer.关键词
宫颈肿瘤/INK4a基因/p16INK4a蛋白/宫颈上皮内瘤变/慢性宫颈炎/子宫平滑肌瘤Key words
cervical neoplasms/INK4a gene/p16INK4a/cervical intraepithelial neoplasia/chronic cervicitis/uterine leiomyoma分类
医药卫生引用本文复制引用
强欣,霍文艳,杨灿,范亚楠,石彩云,白海花..p16INK4a蛋白在蒙古族患者宫颈病变组织中的表达及其意义[J].吉林大学学报（医学版）,2017,43(2):353-355,后插2,4.基金项目
内蒙古自治区科技厅科研基金资助课题(201502103) （201502103）
