吉林大学学报（医学版）2017，Vol.43Issue(2)：369-374,6.DOI:10.13481/j.1671-587x.20170231
甲状腺功能亢进并发急性脑梗死患者临床特点及其静脉溶栓治疗的预后和安全性评价
Clinical characteristics of patients with hyperthyroidism complicated with acute cerebral infarction and evaluation on prognosis and safety of intravenous thrombolysis treatment
摘要
Abstract
Objective:To analyze the clinical characteristics of the patients with hyperthyroidism complicated with acute cerebral infarction, and to evaluate the prognosis and safety of intravenous thrombolysis treatment in the patients with hyperthyrodism complicated with acute cerebral infarctron within time window for thrombolysis. Methods:The clinical materials of patients with acute cerebral infarction treated with intravenous tissue plasminogen activator (rt-pA)were retrospectively analyzed.All patients were divided into hyperthyroidism group (n=41) and non-hyperthyroidismin group (n=160) according to whether complicated with hyperthyroidism.The general imformation,the area of cerebral infarction and intracranial hemorrhage of the patients in two groups were analyzed.Results:The NHISS score of the patients in hyperthyroidism group was higher than that in non-hyperthyroidism group for the first time(P<0.05).The NHISS scores 7 d after treatment and the 90 d modified Rankin scale (mRS) scores had no statistical differences between two groups (P>0.05).The proportions of the different infarction sizes had significant differences between two groups (P<0.05).The patients with large area cerebral infarction in hyperthyroidism group accounted for 51.2%, and it accounted for 27.5% in non-hyperthyroidism group.The incidence of asymptomatic intracranial hemorrhage of the patients in hyperthyroidism group was higher than that in non-hyperthyroidismin group (P< 0.05),but there was no statistical difference in the incidence of intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SHA) between two groups (P > 0.05).Conclusion:The patients with acute cerebral infarction complicated with hyperthyroidism could benefit from intravenous thrombolysis, without the increasing of incidence of spontaneous intracranial hemorrhage (sICH) and SHA.关键词
急性脑梗死/重组组织纤溶酶原激活剂/溶栓治疗/甲状腺功能亢进症Key words
acute cerebral infarction/recombinant tissue plasminogen activator/thrombolysis/hyperthyroidism分类
医药卫生引用本文复制引用
耿玉荣,柳英杰,张慧丽,王宏..甲状腺功能亢进并发急性脑梗死患者临床特点及其静脉溶栓治疗的预后和安全性评价[J].吉林大学学报（医学版）,2017,43(2):369-374,6.基金项目
国家自然科学基金资助课题(81160368) （81160368）
