重庆医学2017，Vol.46Issue(8)：1060-1062,3.DOI:10.3969/j.issn.1671-8348.2017.08.017
脑外伤患者血清炎症细胞因子与颅内压关系的研究
Relationship between inflammatory cytokines and intracranial pressure in patients with traumatic brain injury
摘要
Abstract
Objective This study investigates the relationship of serum irfflammatory cytokine levels with intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI) after surgery.Methods A total of 32 cases with severe TBI and placement of ICP monitor were prospectively enrolled.Serum was collected before surgery and every 12 h after surgery.Cytokines levels of interleukin (IL)-1β,IL-8,and tumor necrosis factor (TNF)-α were analyzed and compared with outcome of patients.Hourly values of ICP were recorded.The degree of ICP above treatment threshold (20 mm Hg) were calculated every 12 h as "pressure times time dose " (PTD-ICP20),which was compared with serum cytokine levels before (Pre) and after (Post) the 12-hour time period using linear regression method.Results Serum IL-1β (P＜0.05),IL-8 (P＜0.01) and TNF-a (P＜0.01) levels elevated dramatically after severe TBI and were significantly associated with outcome of patients.Mean PTD-ICP20 was (42.9 ± 60.2)mm Hg/h and was correlated with increased Pre-IL-8 (r=0.554,P＜0.001),Pre-TNF-α (r=0.597,P＜0.001),Post-IL-8 (r=0.629,P＜0.001) and Post-TNF-α (r=0.538,P＜0.001) levels.Conclusion Serum IL-8 and TNF-α demonstrated the most promising candidate bio.rnarkers of impending ICP elevation in this study.These findings indicate a feasible way of monitoring patients with severe TBI.关键词
脑损伤/颅内压/炎症细胞因子/神经炎症/生物标记物Key words
brain injuries/intracranial pressure/inflammatory cytokine/neuroinflammation/biomarker分类
医药卫生引用本文复制引用
蒋文庆,卞晓星,陈红春,魏文峰,金鹏..脑外伤患者血清炎症细胞因子与颅内压关系的研究[J].重庆医学,2017,46(8):1060-1062,3.基金项目
常州市武进区科研基金资助项目(WS201406). （WS201406）
