重庆医学2017，Vol.46Issue(8)：1066-1069,4.DOI:10.3969/j.issn.1671-8348.2017.08.019
不同肾小球滤过率估算方程在术前肾癌患者中的临床应用研究
The application of different GFR estimation equations in preoperative patients with renal cell carcinoma
吴燕 1谌海兰 2侯玉磊 2毕小云 2徐华建 2胥飚 2陈特2
作者信息
- 1. 重庆医科大学附属第一医院输血科 400016
- 2. 重庆医科大学附属第一医院医学检验科 400016
- 折叠
摘要
Abstract
Objective To evaluate the diagnostic performances of seven estimation formulas for glomerular filtration rate (GFR) in pre-operative patients with renal cell carcinoma.Methods A total of 386 pre-operative patients with renal cell carcinoma in the first affiliated hospital of Chongqing medical university from January 2012 to October 2014 were selected.All the patients' GFRs were measured by the renal dynamic imagingwith 99mTc-DTPA as reference (rGFR) and the seven GFR estimation equations (eGFR) were compared with the rGFR respectively.Their correlations and consistencies were observed with spearman correlation analysis and Bland and Altman analysis.The diagnostic sensitivity,specificity and likelihood ratios were calculated and the eGFR accuracies were assessed with receiver operator curve (ROC) analysis.Results The correlations between the rGFR and eGFRs were significantly (P＜0.001).In addition,CKD-EPI-Asian Crea and Ruijin formula were more accurate than others in different stages with larger ROC area in diagnosing renal cell carcinoma.Conclusion There were significant correlations between the eGFRs and rGFR,but some deviations existed.CKD-EPI-Asian Crea and Ruijin formula were more suitable for assessment of eGFR of pre-operative patients with renal cell carcinoma.However,both of these equations had a few limitations.关键词
肾肿瘤/肾小球滤过率/肾功能/诊断性能Key words
kidney neoplasms/glomerular filtration rate/kidney function/diagnostic performance分类
医药卫生引用本文复制引用
吴燕,谌海兰,侯玉磊,毕小云,徐华建,胥飚,陈特..不同肾小球滤过率估算方程在术前肾癌患者中的临床应用研究[J].重庆医学,2017,46(8):1066-1069,4.
