重庆医学2017，Vol.46Issue(8)：1070-1072,1075,4.DOI:10.3969/j.issn.1671-8348.2017.08.020
注射用尖吻蝮蛇血凝酶在肝切除手术中止血效果及安全性的比较
Comparison of hemostatic effect and safety of injection of Agkistrodon acutus venom coagulation in liver resection
李春桃 1胡小东 1陈果 1胡浩文 1陈涛 1苏松 1李波1
作者信息
- 1. 西南医科大学附属医院肝胆外科,四川泸州646000
- 折叠
摘要
Abstract
Objective To compared hemostatic effect of agkistrodon haemocoagulase and other hemostatic agents in hepatectomy,and observe clinical safety.Methods From November 2014 to February 2016,122 patients undergoing hepatectomy of the department of hepatobiliary surgery in the hospital,according to the inclusion and exclusion criteria,were randomly divided into three groups,which was group A-haemocoagulase agkistrodon for injection,group B-ferdelance haemocoagulase for injection and group Cdesmopressin acetate injection.After drug administration,according to the clinical research plan,the indexes for therapeutic effectsbleeding time of wound,bleeding volume of wound,postoperative drainage volume for 24 h,preoperative and postoperative safety indices-Routine blood test,clotting function,liver and kidney function were compared among the three groups.Results The general data of the 3 groups were comparable.The bleeding time of wound,bleeding volume of wound,postoperative drainage volume for 24 h showed no significant difference(P＞0.05).Routine blood test,coagulation function,liver and kidney function,pre-admi nistration and post-administration administration of the group on the third day between and within groups were compared and showed no significant difference(P＞0.05).ECG and lower extremity ultrasound examination showed no abnormality in each group.No adverse events happened in the cases of groups for the clinical study.Conclusion Hemostatic effects of haemocoagulase agkistrodon for injection and other hemostatic drugs were similar in hepatectomy.No sinificant adverse effects on postoperative routine blood,coagulation function,liver and kidney function,with good efficacy and safety,being worthy of using widely worth in hepatectomy.关键词
肝切除术/注射用尖吻蝮蛇血凝酶/止血效果/安全性Key words
hepatectomy/agkistradon haemocoagulase/hemostatic effect/security分类
医药卫生引用本文复制引用
李春桃,胡小东,陈果,胡浩文,陈涛,苏松,李波..注射用尖吻蝮蛇血凝酶在肝切除手术中止血效果及安全性的比较[J].重庆医学,2017,46(8):1070-1072,1075,4.
