重庆医学2017，Vol.46Issue(9)：1172-1174,1178,4.DOI:10.3969/j.issn.1671-8348.2017.09.006
阿托伐他汀对糖尿病心肌病大鼠心肌组织赖氨酰氧化酶的影响
Effects of atorvastatin on expression of lysyl oxidase in myocardial tissue of rats with diabetic cardiomyopathy
刘会 1张曙影 2荣季冬3
作者信息
- 1. 贵州省人民医院心内科,贵阳550002
- 2. 大连大学附属中山医院心内科,辽宁大连116001
- 3. 遵义医学院附属医院心内科,贵州遵义563000
- 折叠
摘要
Abstract
Objective To study the effects of atorvastatin on expression of lysyl oxidase(LOX) in myocardial tissue of rats with diabetic cardiomyopathy (DCM) and its mechanism.Methods Thirty DCM SD rats were randomly divided into 3 groups:DCM group,treatment group (atorvastain 2 mg · kg-1 · d-1 by gastric gavage) and β-aminopropionitrile group(β-aminopropionitrile 80 mg · kg-1 · d-1 by gastric gavage),10 cases in each group.Other 10 SD rats were selected as the control group.At the end of week 8,the rats were killed for extracting the myocardial tissue RNA and protein.Expression levels of LOX,MMP-2 and NF-κB mRNAs and proteins in myocardial tissue of DCM rats were measured by RT-PCR and Western blot.Results The expression levels of LOX,MMP-2 and NF-κB mRNAs and proteins in the DCM group were significantly higher than those in the control group (P＜0.01),and compared with the DCM group,the expression of BAPN LOX,MMP-2 and NF-κB mRNA and proteins in the treatment group were significantly deceased (P＜0.01).Conclusion Atorvastatin can reverse the expression of LOX in myocardial tissue of DCM rat,and then may regulate the expression of MMP-2 and NF-κB.关键词
糖尿痛心肌病/蛋氨酸-6-氧化酶/基质金属蛋白酶2/NF-κB/阿托伐他汀Key words
diabetic cardiomyopathy/protein-lysine 6-oxidese/matrix metalloproteinase 2/NF-kappa B/atorvastatin分类
医药卫生引用本文复制引用
刘会,张曙影,荣季冬..阿托伐他汀对糖尿病心肌病大鼠心肌组织赖氨酰氧化酶的影响[J].重庆医学,2017,46(9):1172-1174,1178,4.
