重庆医学2017，Vol.46Issue(9)：1240-1245,1248,7.DOI:10.3969/j.issn.1671-8348.2017.09.028
臭氧与透明质酸治疗膝骨性关节炎安全性和有效性的Meta分析
Safety and effectiveness of ozone versus hyaluronic acid for treating knee osteoarthritis:a Meta analysis
胡炳炎 1艾金伟 2刘楚繁 3陈琼 3姚忠军3
作者信息
- 1. 十堰市太和医院/湖北医药学院附属医院显微骨科,湖北十堰442000
- 2. 湖北医药学院附属襄阳医院骨科,湖北襄阳441000
- 3. 湖北医药学院附属襄阳医院循证医学中心,湖北襄阳441000
- 折叠
摘要
Abstract
Objective To compare the safety and effectiveness between ozone (O3) and hyaluronic acid (HA) in treating knee osteoarthritis(KOA) by using the meta analysis method.Methods The relevant randomized controlled trials(RCTs) in PubMed,Cochrane Library (issue 1,2016),Embase,CNKI,CBM,VIP,and Wan-Fang databases were retrieved from their establishment to January 23,2016.Two reviewers independently screened the literatures,extracted the data and evaluated the quality of the included RCTs.The results were performed the statistical analysis by using the RevMan5.3 and Stata13.0 software.Results Twenty RCTs involving 2 136 KOA patients were included.Compared with the HA treatment of KOA,the O3 treatment had higher treatment effective rate[odds ratio(OR) =2.78,P＜0.01],and better pain relief effect[at 1,3,6 month after treatment:mean difference(MD) =-0.25,-0.71,-1.70,P＜0.01].There were no statistically significant differences in complications between the two treatment methods[OR=0.84,P=0.56].Conclusion Current evidences indicate that the short-term therapeutic effect of O3 for KOA is superior to HA,and the safety is similar.关键词
骨关节炎,膝/臭氧/透明质酸/Meta分析Key words
osteoarthritis, knee/ozone/hyaluronic acid/Meta-analysis分类
医药卫生引用本文复制引用
胡炳炎,艾金伟,刘楚繁,陈琼,姚忠军..臭氧与透明质酸治疗膝骨性关节炎安全性和有效性的Meta分析[J].重庆医学,2017,46(9):1240-1245,1248,7.
