摘要
Abstract
Objective To compare the efficiency and safety of risperidone and aripiprazole in treatment of preschool children with attention deficit hyperactivity disorder (ADHD) combined with disruptive behavior disorder (DBD).Methods Thirty-six 3 -6 year-old children diagnosed with ADHD combined with DBD were randomly divided to two groups with 18 cases in each .An 8-week treatment with risperidone or aripiprazole was given to different groups .Assessment was performed by Conners ' rating scale-revised and clinical global impression scale (CGI) before treatment and at end of week 2, 4, and 8 of treatment.Results Conners rating score did not have statistical differences between two groups in any stage of evaluation (P>0.05).After 2-week of treatment, scores of hyperactivity (risperidone group t=2.988, P <0.05; aripiprazole group t =2.682, P <0.05), impaired concentration (risperidone group t =2.988, P <0.05;aripiprazole group t=2.130, P<0.05), ADHD (risperidone group t=2.881, P<0.05; aripiprazole group t=3.756, P<0.05), oppositional defiant disorder (ODD) (risperidone group t=2.988, P<0.05; aripiprazole group t =2.247, P<0.05) and tolerance (risperidone group t=6.255, P<0.05;aripiprazole group t=5.889, P<0.05) in two groups decreased significantly compared to those of pre-treatment, and all differences had statistical significance .Indexes measured at fourth and eighth week of treatment in two groups had no statistically significant difference compared to those at second week of treatment (all P>0.05).Mean increase in weight and fasting blood sugar (FBS) in two groups at end point of treatment were both not significantly different from that before treatment (P>0.05). Increase of mean serum prolactin in risperidone group at end of treatment was higher than that in aripiprazole group , and the difference was statistically significant ( t =34.087, P <0.05).Conclusion Risperidone is similar to aripiprazole in reducing symptoms of ADHD combined with DBD with equal safety , but both drugs show high incidence of side effect .Clinical medication should be cautious .关键词
利培酮/阿立哌唑/注意缺陷多动障碍/破坏性行为障碍Key words
risperidone/aripiprazole/attention deficit hyperactivity disorder (ADHD)/disruptive behavior disorder (DBD)分类
医药卫生
