张景秀 1齐学良 1刘亚萍 1李学敏 1徐本福 1孙相国 1杨军霞1
作者信息
- 1. 临沂市沂水中心医院小儿内三科,山东沂水276400
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摘要
Abstract
Objective To investigate the relationship between urinary monocyte chemotaxis protein -1 (MCP-1) and renal tubular interstitial lesion in IgA nephropathy .Methods A total of 98 patients with primary IgA nephropathy confirmed by renal biopsy were retrospectively studied from March 2012 to August 2015 in Yishui Central Hospital.They were divided into no lesion group (11 cases), mild group (41 cases), moderate group (32 cases) and severe group (14 cases) according to renal tubular interstitial damage degree in biopsy pathology . Urine MCP-1 and related indicators were detected and analyzed .Results The systolic blood pressure and diastolic blood pressure of moderate group and severe group were significantly higher than those of no lesion group and mild group , and the differences had statistical significance (comparing severe group to no lesion group, t value was 4.119 and 5.820;comparing moderate group to mild group, t value was 4.613 and 5.714;comparing severe group to no lesion group , t value was 2.668 and 2.914;comparing severe group to mild group , t value was 2.257 and 2.573, respectively, all P<0.05).Serum creatinine, β2 microglobulin (β2-MG), urinary NAG, 24h urinary protein, and urinary MCP-1 showed increasing trend in no lesion group , mild group, moderate group and severe group , and the differences between two groups had statistical significance (F value was 40.862, 37.851, 62.396, 77.084 and 21.362, respectively, all P<0.05). Creatinine clearance rate in no lesion group , mild group , moderate group and severe group was gradually reduced and the difference between two groups had statistical significance (F=43.396, P<0.05).Serum creatinine of renal tubular matter damage in children with IgA nephropathy,β2-MG and urinary NAG and 24h urinary protein were positively correlated with urinary MCP-1 (r value was 0.671, 0.598, 0.664 and 0.692, respectively, all P<0.05), and creatinine clearance rate was negatively correlated with urinary MCP-1 (r=-0.720, P<0.05).Conclusion MCP-1 can reflect the degree of renal tubular interstitial lesion in children with IgA nephropathy .关键词
尿液/单核细胞趋化蛋白-1/IgA肾病/肾小管间质Key words
urine/monocyte chemotaxis protein-1/IgA nephropathy/renal tubular interstitial分类
医药卫生
