摘要
Abstract
Objective To investigate the diagnostic value of TCT and HPV detection by colposcopic biopsy on cervical lesions .Methods Altogether 1300 outpatients receiving primary screening of cervical cancer were selected as research objects .All cases were detected by colposcopic biopsy , liquid-based thinlayer cytologic test ( TCT) and high risk human papilloma virus ( HPV) DNA test, and colposcopic biopsy result was used as diagnosis criteria .Based on it , diagnostic value of TCT , HPV and their combination detection on early stage of cervical cancer was assessed .Results TCT test showed 234 positive cases (18.00%) and 1066 normal and benign inflammation cases (82.00%).Among 234 positive cases, there were 112 cases (8.62%) of atypical squamous cell lesion , 65 cases (5.00%) of low-grade squamous intraepithelial lesion , 43 cases (3.31%) of high-grade squamous intraepithelial lesion and 14 cases (1.08%) of squamous cell carcinoma.HPV-DNA test showed 679 positive cases (52.23%).The sensitivity of TCT combined with HPV-DNA test was 100.00%. All patients had at least one positive indicator .Sensitivity of single TCT detection was 77.12%, with false negative rate (missed diagnosis rate) of 22.88%.Sensitivity of single HPV detection was 84.50%with false negative rate ( missed diagnosis rate ) of 15.50%.Detection rate of TCT combined with HPV-DNA test was remarkably higher than that of single TCT or HPV test (χ2 value was 27.469 and 17.477, respectively, both P<0.01), and that of single HPV test was higher than that of single TCT test (χ2 =4.759, P<0.05).Conclusion Clinical use of colposcopic biopsy , HPV and TCT for early cervical lesion screening has high efficiency and feasibility .Combined detection of HPV and TCT can improve sensitivity and reduce false negative rate , and it has important value for early screening of cervical cancer .关键词
宫颈病变/阴道镜下活检/液基细胞学检查/人乳头瘤病毒/诊断价值Key words
cervical lesions/colposcopic biopsy/liquid-based thinlayer cytology test(TCT)/human papilloma virus (HPV)/diagnostic value分类
医药卫生
