摘要
Abstract
Objective To analyze the different doses selection of dexmedetomidine combined with propofol for target controlled infusion in painless hysteroscopic surgery and perioperative adverse reactions .Methods Totally 150 cases undergoing painless hysteroscopic surgery were selected in Maternal and Child Health Hospital of Xiangyang City during 2014 to 2016 and were divided into control group including 75 cases with preoperative infusion of 1μg/kg dexmedetomidine and experiment group including 75 cases with preoperative infusion of 0.5μg/kg dexmedetomidine .The pumping was ended in 12 minutes.Target controlled infusion of propofol anesthesia was used and the concentration was controlled according to patients ' disease.The hemodynamics indexes at different time of two groups were observed and pain, nausea and other adverse reactions were compared between two groups during and after surgery .Results The mean arterial pressure (MAR) in two groups before treatment, eliminating mass and after surgery showed no significant difference (t value was -0.98, -0.46 and -0.31, respectively, all P>0.05), and the heart rate (HR) also showed no significant difference (t value was -0.83, -0.53 and -1.03, respectively, all P>0.05).The MAP of two groups after anesthesia and at uterus dilatation was not significantly different (t value was 1.21 and -0.98, respectively, both P>0.05), but HR in the experiment group was significantly higher than that of the control group (t value was 6.87 and 5.63, respectively, both P<0.05).Observer Assessment of Alertness/Sedation Scale (OAA/S) score in the experimental group after treatment was significantly higher than that of the control group (t=8.96, P=0.00) and the awake time was lower than that of the control group (t=-7.93, P=0.00).But propofol dosage showed no significant difference between two groups (t=1.07, P=0.11).The incidence of sleepiness in the experimental group after treatment was far lower than in the control group (χ2 =16.98,P=0.01).The incidence of respiratory depression during operation , boredom, nausea and pain after treatment between two groups showed no significant difference (χ2 value was 2.75, 1.86, 3.04 and 3.15, respectively, all P>0.05).Conclusion The principle of small dose of dexmedetomidine combined with target controlled infusion of propofol should be adopted in painless hysteroscopic surgery , which can reduce the dosage and side-effects of propofol , effectively reduce the adverse reactions after operation with high safety and reliability.关键词
右美托咪定/丙泊酚/宫腔镜手术/麻醉Key words
dexmedetomidine/propofol/hysteroscopic surgery/anesthesia分类
医药卫生
