中国实用神经疾病杂志2016，Vol.19Issue(5)：6-8,3.
氟桂利嗪与维生素B12对高同型半胱氨酸血症干预治疗的效果
Clinical intervention study of flunarizine combined with vitamin B12 in the treatment of hyperhomocysteinemia
摘要
Abstract
Objective To study the clinical effect of flunarizine combined with vitamin B12 on hyperhomocysteinemia.Methods A total of 100 patients with hyperhomocysteinemia were randomly divided into observation group and control group,50 patients in each group.Patients in control group were treated by folic acid and vitamin B12,patients in observation group were treated by flunarizine additionally.The serum cysteine level,the level of vascular endothelial cell damage,haemodynamics before and after treatment were compared between two groups.Results The serum cysteine level after treatment was significantly less than those before treatment in both groups(P＜0.01) and there was no significantly difference between two groups (P＞0.05).The levels of ET-1,NO2-/NO3-,NOS were significantly changed after treatment(P＜0.01) and there was significant difference between the two groups(P＜0.01).The MCAVs level was significantly decreased in both groups(P＜0.01)and significant difference was found between two groups(P＜0.01).Conclusion Flunarizine can reduce the levels of vascular endothelial cell damage in hyperhomocysteinemia patients to improve haemodynamics which makes it available for clinical application.关键词
高同型半胱氨酸血症/氟桂利嗪/维生素B12/血管内皮损伤Key words
Hyperhomocysteinemia/Flunarizine/Vitamin B12/Vascular endothelial cell分类
医药卫生引用本文复制引用
郑书恭,卢翠玲..氟桂利嗪与维生素B12对高同型半胱氨酸血症干预治疗的效果[J].中国实用神经疾病杂志,2016,19(5):6-8,3.基金项目
东莞市科技计划项目,编号:201410515000508 （）
