摘要
Abstract
Objective To explore MRI study of the relationship between micro-hemorrhage and cognitive function in nondementia cerebral small vessel disease (CSVD) patients.Methods All of 100 cases with non-dementia CSVD in our hospital from January 2012 to January 2014 were examined by gradient-echo T2-weighted MRI.According to MRI results,25 cases with positive micro-hemorrhage were classified as observation group and 25 cases without micro-hemorrhage were identified as control group.We performed MoCA scale,MMSE and CDT to evaluate the cognitive function of two groups.Results The abilities of naming,visuospatial execution,calculation,language,memory and abstract generalization of MoCA scale as well as MMSE scores and CDT scores detected in the observation group were lower than that in the control group.On the contrary,patients with white matter damage and lacunar infarct observed in observation group were higher than those in control group with the statistical difference (P＜0.05).The attention ability and orientation capacity of MoCA scale showed no differences between two groups (P＞0.05).Pearson partial correlation analysis indicated that the number of micro-hemorrhage had positive correlation with attention ability,visuospatial executive function,calculation power,had negative correlation with total MoCA score,total CDT score and MMSE scores,and had no correlation with language,naming,delayed memory,disorientation and abstraction.Conclusion Cognitive function can be related to the number of intracerebral micro-hemorrhage in non-dementia CSVD patients;and with the more number of micro-hemorrhage,the cognitive dysfunction should be more severe.Thus,we should take the number of micro-hemorrhage into consideration as a criterion to diagnose the early cognitive dysfunction of CSVD.关键词
脑小血管病/非痴呆/脑微出血灶/认知功能/磁共振成像Key words
Cerebral small vessel disease/Non-dementia/Micro-hemorrhage/Cognitive function/MRI分类
医药卫生
