解放军医学杂志2017，Vol.42Issue(2)：95-102,8.DOI:10.11855/j.issn.0577-7402.2017.02.02
脓毒症免疫紊乱及其临床意义
Immunologic dissonance and its clinical significance in sepsis
摘要
Abstract
Sepsis is essentially a result from immunological dissonance provoked by severe insults such as fulminant infection,severe trauma and extensive burns.It originates from excessive inflammatory responses and develops into immune paralysis or immunosupression.It has been demonstrated that cellular immune response plays a vital role in the pathogenesis of sepsis.In the stage of excessive inflammation,several kinds of immune cells are activated by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) and subsequently produce a vast number of pro-inflammatory cytokines,while during the stage of immune paralysis,excessive apoptosis could result in decrease of immune cells with functional compromise.Inhibitory or regulatory immune cell subsets eventually dominate the direction of immune response and the production of inhibitory cytokines is enhanced.For clinical practice,surveillance of changes and shift in overall immune function is a basis for immunotherapy,especially to immunomodulation therapy.However,there is still a lack of adequate indexes or markers for integral evaluation of host immune state in the development of sepsis.关键词
脓毒症/免疫紊乱/免疫,细胞/细胞凋亡/监测,免疫学Key words
sepsis/immunologic dissonance/immunity, cellular/apoptosis/monitoring, immunologic分类
医药卫生引用本文复制引用
吴田田,姚咏明..脓毒症免疫紊乱及其临床意义[J].解放军医学杂志,2017,42(2):95-102,8.基金项目
国家自然科学基金重点项目(81130035、81372054) （81130035、81372054）
国家重点基础研究发展计划项目(2012CB518102) （2012CB518102）
军队“十二五”计划重大项目(AWS11J008)This work was supported by the National Natural Science Foundation of China (81130035,81372054),the National Program on Key Basic Research Project (973 Program) of China (2012CB518102),and the "Twelfth Five-Year Plan" Major Project of PLA (AWS11J008) （AWS11J008）
