解放军医学杂志2017，Vol.42Issue(2)：140-143,4.DOI:10.11855/j.issn.0577-7402.2017.02.09
前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效观察
Effect of alprostadil on early proinflammatory cytokines and its therapeutic effect in patients with severe acute pancreatitis
摘要
Abstract
Objective To investigate the effects of alprostadil on expression of proinflammatory cytokines in patients with severe acute pancreatitis (SAP) and evaluate the clinical efficacy.Methods Seventy-three SAP patients were collected from January 2014 to May 2016,and then were randomly divided into control group (n=37) and experimental group (n=36).On the basis of routine treatment,the experimental group patient was given alprostadil at a dose of 15μg/d.The expression of C-reactive protein (CRP),white blood cell (WBC) count,amylase,alanine aminotransferase (ALT),aspartate aminotransferase (AST),creatinine,serum proinflammatory cytokine tumor necrosis factor alpha (TNF-α),interleukin-1 beta (IL-1[β),interleukin-6 (IL-6) were detected in serum on the 1st,3rd and 7th day.Results The biochemical indexes and expression ofproinflammatory cytokines were significantly increased in the two groups on the 1st day,and decreased gradually,with a significant difference between the time points (P＜0.05),but the between-group difference was not significant (P＞0.05).These indexes were decreased significantly with the passage of time and there were significant differences between the two groups at the 3rd and 7th day (P＜0.05).Conclusion Alprostadil can effectively reduce the severity of early inflammatory reaction in SAP patients,and has important significance for improving the prognosis.关键词
胰腺炎,急性坏死性/前列地尔/炎症因子Key words
pancreatitis, acute necrotizing/alprostadil/inflammatory cytokines分类
医药卫生引用本文复制引用
李敏利,张晓华,金鑫鑫,许小兵,汪芳裕..前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效观察[J].解放军医学杂志,2017,42(2):140-143,4.基金项目
南京军区保健专项科研课题(14BJZ28)This work was supported by the Health Special Subject of Nanjing Command(14BJZ28) （14BJZ28）
