世界中医药2017，Vol.12Issue(2)：293-298,6.DOI:10.3969/j.issn.1673-7202.2017.02.014
补肾生骨颗粒对肾虚血瘀型绝经后骨质疏松症BMD、E2、BALP、N-MID的影响
Effect of Bushen Shenggu Granules on BMD, Serum E2, BALP, N-MID of Patients Postmenopausal Osteoporosis of Kidney Deficiency and Blood Stasis Type
摘要
Abstract
Objective:Clinical curative effects and advantages of Bushen Shenggu Granules in the treatment of postmenopausal osteoporosis of kidney deficiency and blood stasis type were observed, for providing references for clinical treatment of postmenopausal osteoporosis.Methods:A total number of 112 patients with postmenopausal osteoporosis of kidney deficiency and blood stasis type who met the inclusive criteria and had complete follow-up data were included and randomly divided into the treatment group (56 cases of oral Bushen Shenggu Granules) and the control group (56 cases of oral Gail, D).Improvement of clinical symptoms and signs and changes in bone mineral density (BMD), serum levels of estradiol (E2), bone alkaline phosphatase (BALP), n-terminal osteocalcin (N-MID) of the two groups before and after the treatment were observed.Results:The total efficacy of the treatment group was 67.86% compared with that of the control group of 50.0%, showing statistically significant difference (P<0.05).The curative effect of the treatment group was superior to that of the control group.Syndromes curative effect of treatment group was 89.29% compared with that of the control group of 28.57%, with significant difference (P<0.05).After treatment, there were no changes in serum E2 of the control group after treatment, while serum E2 elevated in the treatment group (P<0.05).BMD in the control group and the treatment group after treatment showed statistical difference (P<0.05).Bone density increased significantly and BALP and N-MID lowered in the treatment group after treatment with a statistically significant difference (P<0.05), and the treatment group was better than that of the control group.Conclusion:Bushen Shenggu Granules for Postmenopausal Osteoporosis of kidney deficiency and blood stasis type has good effect on improving clinical symptoms and may increase BMD, regulate Estrogen levels, neurotransmitters and bone metabolism.It regulates hypothalamus-pituitary-ovarian axis function, promote ovarian hormones, adjust neurotransmitter, in order to reduce bone absorption and promote bone formation and metabolism.关键词
补肾生骨颗粒/肾虚血瘀/绝经后骨质疏松症/临床研究Key words
Bushen Shenggu Granules/Kidney deficiency and blood stasis type/Postmenopausal osteoporosis/Clinical research分类
医药卫生引用本文复制引用
王丽丽,房经武,王金国..补肾生骨颗粒对肾虚血瘀型绝经后骨质疏松症BMD、E2、BALP、N-MID的影响[J].世界中医药,2017,12(2):293-298,6.基金项目
山东省中医药科技发展计划项目(编号:2013ZDZK-143) （编号:2013ZDZK-143）
