世界中医药2017，Vol.12Issue(2)：417-423,7.DOI:10.3969/j.issn.1673-7202.2017.02.046
从长链非编码RNA角度探讨针灸治疗IBD的效应及调节机制
Discussing the Effective Mechanism of Acupuncture and Moxibustion in Inflammatory Bowel Disease from Long Non-coding RNAs
摘要
Abstract
Inflammatory bowel disease (IBD),including crohn′s disease and ulcerative colitisis,are chronic inflammatory diseases with unclear etiology and pathogenesis.The effect of acupuncture and moxibustion on the treatment of IBD is curative and has significant advantages,but its mechanisms still need to be further studied.Studies in recent years found that lncRNAs widely involved in the physiological and pathological process of the body,especially mediating the immune inflammatory response through gene regulation,and have close relationship with variety autoimmune diseases that including IBD.A variety of lncRNAs differently expressed when IBD occurs,and the abnormal expression and function of lncRNAs play an important role in the development of IBD inflammation.In this article,the functions of lncRNA as well as research progress of its relationship with IBD are summarized,and then base on the treatment of acupuncture and moxibustion on IBD,we in order to study whether acupuncture and moxibustion regulate the inflammatory response of IBD through regulating related lncRNAs,which will provide new ideas for the research on the mechanism of acupuncture and moxibustion on the treatment of IBD.关键词
IBD/中医针灸/长链非编码RNA/疗效机制/思考与展望Key words
Inflammatory bowel disease (IBD)/Acupuncture and moxibustion/Long non-coding RNA/Effective mechanism/Thought and prospect分类
医药卫生引用本文复制引用
顾沐恩,吴焕淦,刘雅楠,张琳珊,刘慧荣,赵继梦,李晨,李璟..从长链非编码RNA角度探讨针灸治疗IBD的效应及调节机制[J].世界中医药,2017,12(2):417-423,7.基金项目
上海市青年科技英才扬帆计划资助(编号:17YF1417600) （编号:17YF1417600）
